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Cefamandole sodium (CMD) was intravenously administered and following laboratoric and clinical results were obtained. (1) The peak blood concentration was 32 approximately 44 micrograms/ml when the drip infusion was finished. At 1 hour after the end of the drip infusion the blood concentration was 7.6 approximately 8.1 micrograms/ml. Half life was approximately 0.64 hours. (2) Urinary recovery rate was 84.5 approximately 95% in active state within 6 hours. (3) Penetration of cerebrospinal fluid was found in 2 cases. (4) In most of 170 strains of Streptococcus haemolyticus MICs of cefamandole were 0.05 microgram/ml. They were less susceptible to cefazoline, cefmetazole and ceftezole. (5) CMD was administered to 35 pediatric patients (upper or lower RTI, lymphadenitis, enteritis or UTI) at 100 mg/kg/day for 3 approximately 9 days, the efficacy rate was 97.1%. (6) Side effect: Rash occurred in one case, and eosinophilia was observed in 4 cases. No abnormal finding of renal and liver function was observed.
S Nakazawa, and
H Satoh, and
K Niino, and
S Nakazawa, and
H Suzuki, and
A Iwasaki, and
H Chikaoka, and
S Oka, and
Y Hirama, and
A Narita
November 1979,
The Japanese journal of antibiotics,
S Nakazawa, and
H Satoh, and
K Niino, and
S Nakazawa, and
H Suzuki, and
A Iwasaki, and
H Chikaoka, and
S Oka, and
Y Hirama, and
A Narita
April 1980,
The Japanese journal of antibiotics,
S Nakazawa, and
H Satoh, and
K Niino, and
S Nakazawa, and
H Suzuki, and
A Iwasaki, and
H Chikaoka, and
S Oka, and
Y Hirama, and
A Narita
September 1979,
The Japanese journal of antibiotics,
S Nakazawa, and
H Satoh, and
K Niino, and
S Nakazawa, and
H Suzuki, and
A Iwasaki, and
H Chikaoka, and
S Oka, and
Y Hirama, and
A Narita
September 1979,
The Japanese journal of antibiotics,
S Nakazawa, and
H Satoh, and
K Niino, and
S Nakazawa, and
H Suzuki, and
A Iwasaki, and
H Chikaoka, and
S Oka, and
Y Hirama, and
A Narita
October 1979,
The Japanese journal of antibiotics,
S Nakazawa, and
H Satoh, and
K Niino, and
S Nakazawa, and
H Suzuki, and
A Iwasaki, and
H Chikaoka, and
S Oka, and
Y Hirama, and
A Narita
December 1981,
The Japanese journal of antibiotics,
S Nakazawa, and
H Satoh, and
K Niino, and
S Nakazawa, and
H Suzuki, and
A Iwasaki, and
H Chikaoka, and
S Oka, and
Y Hirama, and
A Narita
September 1980,
The Japanese journal of antibiotics,
S Nakazawa, and
H Satoh, and
K Niino, and
S Nakazawa, and
H Suzuki, and
A Iwasaki, and
H Chikaoka, and
S Oka, and
Y Hirama, and
A Narita
March 1981,
The Japanese journal of antibiotics,
S Nakazawa, and
H Satoh, and
K Niino, and
S Nakazawa, and
H Suzuki, and
A Iwasaki, and
H Chikaoka, and
S Oka, and
Y Hirama, and
A Narita
March 1981,
The Japanese journal of antibiotics,
S Nakazawa, and
H Satoh, and
K Niino, and
S Nakazawa, and
H Suzuki, and
A Iwasaki, and
H Chikaoka, and
S Oka, and
Y Hirama, and
A Narita
April 1976,
The Japanese journal of antibiotics,
