Biomaterial Database

Blood levels of diazepam (Valium) and N-desmethyl diazepam in the epileptic child. A preliminary report. 1971

A Viala, and J P Cano, and C Dravet, and C A Tassinari, and J Roger

UI	MeSH Term	Description	Entries
D007275	Injections, Intravenous	Injections made into a vein for therapeutic or experimental purposes.	Intravenous Injections,Injection, Intravenous,Intravenous Injection
D008297	Male		Males
D010634	Phenobarbital	A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.	Phenemal,Phenobarbitone,Phenylbarbital,Gardenal,Hysteps,Luminal,Phenobarbital Sodium,Phenobarbital, Monosodium Salt,Phenylethylbarbituric Acid,Acid, Phenylethylbarbituric,Monosodium Salt Phenobarbital,Sodium, Phenobarbital
D010672	Phenytoin	An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.	Diphenylhydantoin,Fenitoin,Phenhydan,5,5-Diphenylhydantoin,5,5-diphenylimidazolidine-2,4-dione,Antisacer,Difenin,Dihydan,Dilantin,Epamin,Epanutin,Hydantol,Phenytoin Sodium,Sodium Diphenylhydantoinate,Diphenylhydantoinate, Sodium
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D003975	Diazepam	A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.	7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one,Apaurin,Diazemuls,Faustan,Relanium,Seduxen,Sibazon,Stesolid,Valium
D004338	Drug Combinations	Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.	Drug Combination,Combination, Drug,Combinations, Drug
D004569	Electroencephalography	Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.	EEG,Electroencephalogram,Electroencephalograms
D004827	Epilepsy	A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)	Aura,Awakening Epilepsy,Seizure Disorder,Epilepsy, Cryptogenic,Auras,Cryptogenic Epilepsies,Cryptogenic Epilepsy,Epilepsies,Epilepsies, Cryptogenic,Epilepsy, Awakening,Seizure Disorders
D005260	Female		Females

Related Publications

A Viala, and J P Cano, and C Dravet, and C A Tassinari, and J Roger

EEG changes after intravenous diazepam (Valium). A preliminary report.

November 1969, Electroencephalography and clinical neurophysiology,

A Viala, and J P Cano, and C Dravet, and C A Tassinari, and J Roger

Diazepam (Valium) treatment in childhood sleep disorders. A preliminary investigation.

August 1971, Diseases of the nervous system,

A Viala, and J P Cano, and C Dravet, and C A Tassinari, and J Roger

[Intravenous diazepam (Valium) in the treatment of mal epileptic states. A double blind study].

January 1968, Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology,

A Viala, and J P Cano, and C Dravet, and C A Tassinari, and J Roger

[Injectable diazepam (Seduxen, Valium) in the treatment of recurrent epileptic seizures in childhood].

January 1972, Orvosi hetilap,

A Viala, and J P Cano, and C Dravet, and C A Tassinari, and J Roger

Proceedings: Blood diazepam levels: preliminary results.

August 1973, British journal of anaesthesia,

A Viala, and J P Cano, and C Dravet, and C A Tassinari, and J Roger

[Diazepam (Valium) in anesthesiology].

January 1968, Neurocirugia,

A Viala, and J P Cano, and C Dravet, and C A Tassinari, and J Roger

Diazepam (Valium) in hypertension.

November 1974, The Medical letter on drugs and therapeutics,