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The amount of free and protein-bound thiamin diphosphate (TDP) in the liver hyaloplasm of B1 vitamin deficient rats has been measured. In the norm the content of protein-bound TDP remains stable (4.5--4.7 micrograms/g tissue) and does not grow upon thiamin injections. The level of the free coenzyme varies appreciably: in the B1-avitaminotic state the content of free TDP decreases, and in the B1-saturated condition it may exceed the norm 4 times. In the liver this enzyme occurs only as a holoenzyme. In case of B1 vitamin deficiency in the diet the transketolase apoform cannot be detected in the liver. A new model for rapid generation of B1-avitaminosis characterized by a significantly lower level of free and bound TDP is described.
Iu M Ostrovskiĭ, and
A I Voskoboev, and
E A Gritsenko, and
V V Grushnik
September 1985,
Biokhimiia (Moscow, Russia),
Iu M Ostrovskiĭ, and
A I Voskoboev, and
E A Gritsenko, and
V V Grushnik
January 1969,
Voprosy meditsinskoi khimii,
Iu M Ostrovskiĭ, and
A I Voskoboev, and
E A Gritsenko, and
V V Grushnik
December 1954,
La Presse medicale,
Iu M Ostrovskiĭ, and
A I Voskoboev, and
E A Gritsenko, and
V V Grushnik
February 1962,
Experimental cell research,
Iu M Ostrovskiĭ, and
A I Voskoboev, and
E A Gritsenko, and
V V Grushnik
April 1960,
Experimental cell research,
Iu M Ostrovskiĭ, and
A I Voskoboev, and
E A Gritsenko, and
V V Grushnik
May 1979,
Biokhimiia (Moscow, Russia),
Iu M Ostrovskiĭ, and
A I Voskoboev, and
E A Gritsenko, and
V V Grushnik
January 1974,
Nutrition and metabolism,
Iu M Ostrovskiĭ, and
A I Voskoboev, and
E A Gritsenko, and
V V Grushnik
May 1958,
Bollettino della Societa italiana di biologia sperimentale,
Iu M Ostrovskiĭ, and
A I Voskoboev, and
E A Gritsenko, and
V V Grushnik
January 1990,
Ukrainskii biokhimicheskii zhurnal (1978),
Iu M Ostrovskiĭ, and
A I Voskoboev, and
E A Gritsenko, and
V V Grushnik
January 1959,
Internationale Zeitschrift fur Vitaminforschung. International journal of vitamin research. Journal international de vitaminologie,
