Spatial memory deficit following fimbria-fornix lesions: independent of time for stimulus processing. 1979

J A Walker, and D S Olton

The present experiment examined the possible role of stimulus processing time in the spatial memory deficit found following fimbria-fornix lesions in rats. Rats were trained preoperatively on a radial arm maze in a procedure that placed them at the end of each arm and confined them there for 30 seconds. This confinement period was markedly longer than the few seconds the rats normally spend there in the usual test procedure. Rats with fimbria-fornix lesions performed no better than expected by chance on the first choice after placements. Although performance on subsequent choices was above chance, this was due to a strong turning pattern; when this pattern was interrupted, performance was no greater than that expected by chance on all choices. These data demonstrate that the deficit in the radial arm maze resulted primarily from a difficulty in spatial memory, rather than from an insufficient time for processing stimulus information.

UI MeSH Term Description Entries
D008297 Male Males
D008568 Memory Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.
D004193 Discrimination Learning Learning that is manifested in the ability to respond differentially to various stimuli. Discriminative Learning,Discrimination Learnings,Discriminative Learnings,Learning, Discrimination,Learning, Discriminative
D006624 Hippocampus A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation. Ammon Horn,Cornu Ammonis,Hippocampal Formation,Subiculum,Ammon's Horn,Hippocampus Proper,Ammons Horn,Formation, Hippocampal,Formations, Hippocampal,Hippocampal Formations,Hippocampus Propers,Horn, Ammon,Horn, Ammon's,Proper, Hippocampus,Propers, Hippocampus,Subiculums
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013037 Spatial Behavior Reactions of an individual or groups of individuals with relation to the immediate surrounding area including the animate or inanimate objects within that area. Behavior, Spatial,Behaviors, Spatial,Spatial Behaviors
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

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