-transparent.png){kind=logo}
The anorectic activity of diethylpropion and d-amphetamine was studied in rats subjected to various treatments known to affect brain monoamines. The effect of diethylpropion, like that of d-amphetamine, was completely prevented by a lesion of the ventral noradrenergic bundle, which selectively decreases brain noradrenaline, but was not significantly modified in desipramine pretreated rats by an intraventricular injection of 6-hydroxydopamine, a condition decreasing only dopamine. Pretreatment with penfluridol significantly reduced the effect of d-amphetamine but not that of diethylpropion. A non-significant reduction of drug effect was found with alpha-methyl-p-tyrosine. Lesion of the nucleus medianus raphe, which destroys central serotonin neurons, or treatment with methergoline, a central serotonin antagonist, caused no changes in the effects of both compounds. The findings show that integrity of central noradrenergic neurons is an important condition for diethylpropion and d-amphetamine to exert their anorectic effect. Dopamine does not seem to play any role in the effect of diethylpropion but might contribute to that of d-amphetamine. The data are against any involvement of brain serotonin in diethylpropion anorexia.
F Borsini, and
C Bendotti, and
M Carli, and
E Poggesi, and
R Samanin
November 1966,
Il Farmaco; edizione pratica,
F Borsini, and
C Bendotti, and
M Carli, and
E Poggesi, and
R Samanin
September 1976,
Israel journal of medical sciences,
F Borsini, and
C Bendotti, and
M Carli, and
E Poggesi, and
R Samanin
January 1967,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
F Borsini, and
C Bendotti, and
M Carli, and
E Poggesi, and
R Samanin
May 1977,
European journal of pharmacology,
F Borsini, and
C Bendotti, and
M Carli, and
E Poggesi, and
R Samanin
August 2018,
Drug development research,
F Borsini, and
C Bendotti, and
M Carli, and
E Poggesi, and
R Samanin
May 1970,
British journal of pharmacology,
F Borsini, and
C Bendotti, and
M Carli, and
E Poggesi, and
R Samanin
January 1968,
The Journal of clinical pharmacology and the journal of new drugs,
F Borsini, and
C Bendotti, and
M Carli, and
E Poggesi, and
R Samanin
January 1973,
Acta pharmacologica et toxicologica,
F Borsini, and
C Bendotti, and
M Carli, and
E Poggesi, and
R Samanin
January 1989,
Acta cientifica venezolana,
F Borsini, and
C Bendotti, and
M Carli, and
E Poggesi, and
R Samanin
May 1961,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
