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A 90-day study involving administration of O (group 1), 100 (group 2), 250 (group 3) and 500 mg/kg (group 4) of ammonium sulfamate to rats 6 days a week was carried out. No adverse effect was observed in respect of appearance, behaviour or survival of animals. No significant difference in the body weights of rats was observed except in case of adult rats (group 4) where the body weight was significantly less than the controls after the end of 60 days. In all the groups food intake gradually reduced whereas water intake increased as the experiment proceeded. No significant change in relative organ weights were noticed in all groups of rats. Haematological examination conducted at 30, 60 and 90 days revealed non-significant increase in the neutrophils in the adults and male weanling rats (group 4) after 90 days. In the histological examination, organs in all the groups of animals appeared normal except that the liver of 1 rat in adults (group 4) showed slight fatty degenerative changes after 90 days.
B N Gupta, and
R N Khanna, and
K K Datta
May 1963,
Gigiena truda i professional'nye zabolevaniia,
B N Gupta, and
R N Khanna, and
K K Datta
February 1977,
Toxicology,
B N Gupta, and
R N Khanna, and
K K Datta
July 2016,
Toxicology letters,
B N Gupta, and
R N Khanna, and
K K Datta
August 2010,
Fundamental & clinical pharmacology,
B N Gupta, and
R N Khanna, and
K K Datta
May 1948,
Journal of the American Chemical Society,
B N Gupta, and
R N Khanna, and
K K Datta
May 1948,
Journal of the American Chemical Society,
B N Gupta, and
R N Khanna, and
K K Datta
July 2005,
Journal of occupational health,
B N Gupta, and
R N Khanna, and
K K Datta
July 2017,
Mutation research. Genetic toxicology and environmental mutagenesis,
B N Gupta, and
R N Khanna, and
K K Datta
January 1976,
Annales pharmaceutiques francaises,
B N Gupta, and
R N Khanna, and
K K Datta
March 1988,
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao,
