-transparent.png){kind=logo}
The effects of methionine and ethionine on the fine structure of hepatic cell nucleoli of guinea pigs and rats were investigated. A single intraperitoneal injection of methionine into guinea pigs results in the disruption of nucleolonema as early as 2 hours after the injection. By 4 hours, nucleoli show complete fragmentation consisting of many small fragments and small remnants of nucleoli. Large aggregates of interchromatinic granules and condensation of chromatin appear in the nucleoplasm. These changes are remarkably similar to the lesions induced by ethionine in the liver of the rat or the guinea pig. The methionine-induced nuclear and nucleolar lesions persist up to 10 hours after the injection. The administration of adenine 4 hours after the methionine injection reverses the nucleolar lesions by 8 hours. The appearance of incompletely reconstructed nucleoli with twisted ropelike structures suggests a pattern of recovery very similar to the adenine-induced nucleolar reformation in ethionine-treated rats. Injecting methionine into rats induced no nucleolar abnormalities. It is suggested that the mechanism of nucleolar fragmentation induced by methionine or ethionine is related to the accumulation of S-adenosyl compounds with concomitant ATP deficiency in the liver.
H Shinozuka, and
L W Estes, and
E Farber
July 1973,
Laboratory investigation; a journal of technical methods and pathology,
H Shinozuka, and
L W Estes, and
E Farber
September 1977,
British poultry science,
H Shinozuka, and
L W Estes, and
E Farber
February 1968,
The Journal of cell biology,
H Shinozuka, and
L W Estes, and
E Farber
August 1950,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
H Shinozuka, and
L W Estes, and
E Farber
June 1963,
The Journal of biological chemistry,
H Shinozuka, and
L W Estes, and
E Farber
March 1954,
The American journal of physiology,
H Shinozuka, and
L W Estes, and
E Farber
October 1976,
The Journal of pharmacy and pharmacology,
H Shinozuka, and
L W Estes, and
E Farber
March 1980,
Toxicology letters,
H Shinozuka, and
L W Estes, and
E Farber
June 1972,
Experimental and molecular pathology,
H Shinozuka, and
L W Estes, and
E Farber
February 1981,
Toxicology letters,
