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The automated-activated coagulation time, manual-activated coagulation time and the activated partial thromboplastin time were compared to the whole blood clotting time in the measurement of hypocoagulation of heparinized blood. The normal ranges and degree of reproducibility were determined for each clotting assay. Each method was examined for its sensitivity to various concentrations of heparin. In addition, blood samples from patients treated with heparin were assayed by all four methods and their results were compared. The results indicated that the manual-activated clotting time correlated best with the whole blood clotting time, was sensitive to low concentrations of heparin, formed a discernible clot within a convenient time period in blood containing high concentrations of heparin, was reproducible and was easily performed.
A S Kurec, and
M W Morris, and
F R Davey
May 1994,
Catheterization and cardiovascular diagnosis,
A S Kurec, and
M W Morris, and
F R Davey
November 1993,
The Canadian journal of cardiology,
A S Kurec, and
M W Morris, and
F R Davey
October 1995,
The Annals of pharmacotherapy,
A S Kurec, and
M W Morris, and
F R Davey
January 2002,
The Annals of pharmacotherapy,
A S Kurec, and
M W Morris, and
F R Davey
August 1992,
Catheterization and cardiovascular diagnosis,
A S Kurec, and
M W Morris, and
F R Davey
March 1971,
Canadian Medical Association journal,
A S Kurec, and
M W Morris, and
F R Davey
May 1980,
World journal of surgery,
A S Kurec, and
M W Morris, and
F R Davey
August 1983,
Anesthesia and analgesia,
A S Kurec, and
M W Morris, and
F R Davey
April 2017,
Seminars in thrombosis and hemostasis,
A S Kurec, and
M W Morris, and
F R Davey
June 2003,
Artificial organs,
