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The effect of simultaneous administration of 250 mg L-dopa + 25 mg L-carbidopa (Nacom) and 1 mg propranolol/kg body weight (maximal dose 40 mg propranolol) on growth-hormone secretion was tested in 96 children with growth retardation. The results were compared with those in a group of children that had been receiving only L-dopa and L-carbidopa. The additional administration of propranolol reduced the number of children unresponsive to adequate growth-hormone stimulation from 16% to 9.5%. There was no significant difference in mean maximal growth-hormone level between both groups, but the addition of propranolol caused a more long-lasting rise in serum growth hormone levels. Some of the children who previously had failed to have a satisfactory rise in growth-hormone level after L-dopa and L-carbidopa showed satisfactory stimulation when propranolol was added. Since only three blood samples need be taken (0, 45 and 90 minutes) and no significant side effects were noted, the combined treatment is suitable for out-patient use.
W Schönberger, and
W Grimm, and
R Ziegler
June 1974,
Biomedicine / [publiee pour l'A.A.I.C.I.G.],
W Schönberger, and
W Grimm, and
R Ziegler
May 1976,
MMW, Munchener medizinische Wochenschrift,
W Schönberger, and
W Grimm, and
R Ziegler
March 1972,
La Nouvelle presse medicale,
W Schönberger, and
W Grimm, and
R Ziegler
September 1974,
L'union medicale du Canada,
W Schönberger, and
W Grimm, and
R Ziegler
December 1970,
The New England journal of medicine,
W Schönberger, and
W Grimm, and
R Ziegler
July 1979,
Kinderarztliche Praxis,
W Schönberger, and
W Grimm, and
R Ziegler
January 1976,
Lille medical : journal de la Faculte de medecine et de pharmacie de l'Universite de Lille,
W Schönberger, and
W Grimm, and
R Ziegler
November 1973,
The Journal of clinical endocrinology and metabolism,
W Schönberger, and
W Grimm, and
R Ziegler
August 1974,
Rivista di patologia nervosa e mentale,
W Schönberger, and
W Grimm, and
R Ziegler
July 1979,
Southern medical journal,
