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R. factors conferring resistance to penicillins and cephalosporins were transferred by conjugation from six strains of Shigella and from four strains of Salmonella typhimurium to a standard strain of S. typhimurium LT2. The beta-lactamases produced were then characterized by using cell-free extracts. The enzymes were of two types, I and II, with respect to specific activity against benzyl penicillin, substrate profile, K(m), pH optimum, temperature optimum, inhibition by chloride and nitrate ions, and heat inactivation. The six type I enzymes were associated with R factors from Shigella strains; five of these were R(f) factors. The four type II enzymes were associated with R factors from S. typhimurium; all these were R(i) factors.
P H Jenkins, and
W T Drabble
January 1976,
Acta microbiologica Academiae Scientiarum Hungaricae,
P H Jenkins, and
W T Drabble
September 1973,
Japanese journal of microbiology,
P H Jenkins, and
W T Drabble
May 1976,
Nihon saikingaku zasshi. Japanese journal of bacteriology,
P H Jenkins, and
W T Drabble
January 1976,
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases,
P H Jenkins, and
W T Drabble
July 1973,
The Journal of infectious diseases,
P H Jenkins, and
W T Drabble
June 1969,
Japanese journal of microbiology,
P H Jenkins, and
W T Drabble
March 1974,
Antimicrobial agents and chemotherapy,
P H Jenkins, and
W T Drabble
January 1974,
National Institute of Animal Health quarterly,
P H Jenkins, and
W T Drabble
January 1969,
Zeitschrift fur allgemeine Mikrobiologie,
P H Jenkins, and
W T Drabble
January 1972,
Annali Sclavo; rivista di microbiologia e di immunologia,
