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The reaction of Freund adjuvant-immunized cavies to subsequent injection of Mycobacterium tuberculosis H37Ra is confirmed as an immunologically mediated phenomenon. Ultrasonic disruption of mycobacteria to be injected as "challenge" markedly increases the intensity of the consequent 24-48 h reaction and subsequent fibrosis in Freund adjuvant-sensitized cavies and has an apparently inhibiting effect on the extent of subsequent granuloma formation with marked reduction of the density of epithelioid cells. From this study, the 24-48 h reaction to injection of M. tuberculosis into sensitized animals appears clearly to be separable from subsequent granuloma formation depending upon the integrity or otherwise of the injected myocobacteria used as the challenge injection material.
J B Blennerhassett, and
L O Simpson, and
C J Newhook
February 1965,
Igaku to seibutsugaku. Medicine and biology,
J B Blennerhassett, and
L O Simpson, and
C J Newhook
May 1939,
The American journal of pathology,
J B Blennerhassett, and
L O Simpson, and
C J Newhook
November 1965,
Arerugi = [Allergy],
J B Blennerhassett, and
L O Simpson, and
C J Newhook
July 1952,
American review of tuberculosis,
J B Blennerhassett, and
L O Simpson, and
C J Newhook
July 1933,
The Journal of experimental medicine,
J B Blennerhassett, and
L O Simpson, and
C J Newhook
November 1937,
The Journal of experimental medicine,
J B Blennerhassett, and
L O Simpson, and
C J Newhook
June 1984,
Infection and immunity,
J B Blennerhassett, and
L O Simpson, and
C J Newhook
September 1970,
Cellular immunology,
J B Blennerhassett, and
L O Simpson, and
C J Newhook
January 1950,
Problemy tuberkuleza,
J B Blennerhassett, and
L O Simpson, and
C J Newhook
March 1966,
Arerugi = [Allergy],
