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A comparison was made of the blastogenic responses of peripheral lymphocytes (BRPL) of normal sheep with those of sheep bearing ovine squamous cell carcinoma (OSCC). In normal tumour-free sheep, BRPL to phytomitogens were found to vary in different age groups, and BRPL to OSCC extracts were found to become significantly elevated in sheep over one year old. In tumour-bearing mature sheep, BRPL to phytomitogens and to OSCC extracts decreased significantly with increasing maturity of tumours. The results are interpreted to show that increasing tumour volume, due to natural growth or enhancement, associates with increasing suppression of cell-mediated responses, and that such suppression may be a cause and a result of increased tumour volume.
M H Jun, and
R H Johnson, and
J M Mills
January 1978,
Research in veterinary science,
M H Jun, and
R H Johnson, and
J M Mills
December 1969,
Journal of immunology (Baltimore, Md. : 1950),
M H Jun, and
R H Johnson, and
J M Mills
March 1998,
Cancer immunology, immunotherapy : CII,
M H Jun, and
R H Johnson, and
J M Mills
October 1976,
Laboratory animal science,
M H Jun, and
R H Johnson, and
J M Mills
October 1971,
Clinical and experimental immunology,
M H Jun, and
R H Johnson, and
J M Mills
January 1990,
Toxicology in vitro : an international journal published in association with BIBRA,
M H Jun, and
R H Johnson, and
J M Mills
January 2019,
Polish journal of pathology : official journal of the Polish Society of Pathologists,
M H Jun, and
R H Johnson, and
J M Mills
October 1979,
British journal of cancer,
M H Jun, and
R H Johnson, and
J M Mills
December 1958,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M H Jun, and
R H Johnson, and
J M Mills
April 1982,
The American journal of pathology,
