Biomaterial Database

Histopathological reactivity of carotid arteries of normotensive Sprague-Dawley vs spontaneously hypertensive rats to ligation injury. 1979

B C Wexler

The common carotid arteries of normotensive non-arteriosclerotic Sprague-Dawley (S-D) rats, mildly hypertensive but arteriosclerotic breeder S-D rats, severely hypertensive but non-arteriosclerotic virgin spontaneously hypertensive rats (SHR), and severely hypertensive breeder SHR were ligated to induce injury. Three weeks post-ligation, the animals were killed and histopathological sections of the ligated artery demonstrated myointimal proliferation without occlusion in the normotensive S-D rats but myointimal proliferation with occlusion in the severely hypertensive SHR. Breeder S-D rats with moderate hypertension manifested a high incidence of total occlusion by combined myointimal proliferation and thrombosis. Severely hypertensive breeder SHR manifested a high incidence of massive thrombi containing cholesterol clefts causing total occlusion of the injured artery. It is suggested that the severity of the hypertension and the hormonal-metabolic milieu conditions the morphologic response of the arterial wall to injury.

UI	MeSH Term	Description	Entries
D006973	Hypertension	Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.	Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D008297	Male		Males
D009131	Muscle, Smooth, Vascular	The nonstriated involuntary muscle tissue of blood vessels.	Vascular Smooth Muscle,Muscle, Vascular Smooth,Muscles, Vascular Smooth,Smooth Muscle, Vascular,Smooth Muscles, Vascular,Vascular Smooth Muscles
D002339	Carotid Arteries	Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.	Arteries, Carotid,Artery, Carotid,Carotid Artery
D002341	Carotid Artery Thrombosis	Blood clot formation in any part of the CAROTID ARTERIES. This may produce CAROTID STENOSIS or occlusion of the vessel, leading to TRANSIENT ISCHEMIC ATTACK; CEREBRAL INFARCTION; or AMAUROSIS FUGAX.	Thrombosis, Carotid Artery,Carotid Thrombosis,Common Carotid Artery Thrombosis,External Carotid Artery Thrombosis,Internal Carotid Artery Thrombosis,Thrombosis, Carotid,Thrombosis, Common Carotid Artery,Thrombosis, External Carotid Artery,Thrombosis, Internal Carotid Artery,Carotid Artery Thromboses
D002784	Cholesterol	The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.	Epicholesterol
D005260	Female		Females
D005352	Fibromuscular Dysplasia	An idiopathic, segmental, nonatheromatous disease of the musculature of arterial walls, leading to STENOSIS of small and medium-sized arteries. There is true proliferation of SMOOTH MUSCLE CELLS and fibrous tissue. Fibromuscular dysplasia lesions are smooth stenosis and occur most often in the renal and carotid arteries. They may also occur in other peripheral arteries of the extremity.	Fibromuscular Dysplasia of Arteries,Arteries Fibromuscular Dysplasia,Arteries Fibromuscular Dysplasias,Dysplasia, Fibromuscular,Fibromuscular Dysplasias
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001161	Arteriosclerosis	Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.	Arterioscleroses