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The immune defense system of the kidney was studied by inducing ascending pyelonephritis in rats with Corynebacterium renale. With the fluorescent antibody technique, C renale organisms were observed in the renal pelvis, but were not coated with antibody until they reached the medulla. Histopathologic evaluation of renal tissues collected serially after inoculation confirmed the presence of infection in the medulla when antibody coating occurred. Serum anti-C renale antibody concentrations increased after antibody-coated bacteria appeared in the urine and kidney. Free anti-C renale antibody was not detected in urine from infected rats, using the microagglutination assay. Antibody coating appears to occur only after C renale organisms invade the medulla during ascending pyelonephritis.
J A Appleton, and
E V DeBuysscher, and
S Kadis
December 1977,
Infection and immunity,
J A Appleton, and
E V DeBuysscher, and
S Kadis
August 1978,
Infection and immunity,
J A Appleton, and
E V DeBuysscher, and
S Kadis
February 1985,
American journal of veterinary research,
J A Appleton, and
E V DeBuysscher, and
S Kadis
April 1977,
Infection and immunity,
J A Appleton, and
E V DeBuysscher, and
S Kadis
October 1977,
Canadian journal of microbiology,
J A Appleton, and
E V DeBuysscher, and
S Kadis
September 1981,
The Veterinary record,
J A Appleton, and
E V DeBuysscher, and
S Kadis
January 1993,
The British veterinary journal,
J A Appleton, and
E V DeBuysscher, and
S Kadis
December 1981,
Canadian journal of microbiology,
J A Appleton, and
E V DeBuysscher, and
S Kadis
January 1968,
National Institute of Animal Health quarterly,
J A Appleton, and
E V DeBuysscher, and
S Kadis
January 1972,
Research in veterinary science,
