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1 The hypotensive action of labetalol was evaluated during 24 h by continuous intra-arterial ambulatory monitoring in 14 patients. The dose used ranged from 300--1800 mg daily. 2 The drug caused a significant reduction of systolic BP in 19 and diastolic BP in 20 of the 24 h of monitoring. Heart rate was also reduced but less markedly than BP. 3 The rapid early morning increase in BP was also effectively controlled. 4 The mild pre-waking increase in BP was not significantly reduced. 5 Labetalol treatment reduced the variation in systolic BP from the lowest observed quarter-hourly mean as compared with pre-treatment values. 6 The quarter hourly mean values were consistently smooth and revealed no sudden variations which might have resulted from postural hypotension.
V Balasubramanian, and
S Mann, and
E B Raftery, and
M W Millar-Craig, and
D Altman
February 1993,
American journal of kidney diseases : the official journal of the National Kidney Foundation,
V Balasubramanian, and
S Mann, and
E B Raftery, and
M W Millar-Craig, and
D Altman
June 1992,
Revista medica de Chile,
V Balasubramanian, and
S Mann, and
E B Raftery, and
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Advances in peritoneal dialysis. Conference on Peritoneal Dialysis,
V Balasubramanian, and
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D Altman
August 2004,
Blood pressure monitoring,
V Balasubramanian, and
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E B Raftery, and
M W Millar-Craig, and
D Altman
February 1995,
The American journal of cardiology,
V Balasubramanian, and
S Mann, and
E B Raftery, and
M W Millar-Craig, and
D Altman
January 1982,
Medical informatics = Medecine et informatique,
V Balasubramanian, and
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E B Raftery, and
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D Altman
March 1995,
American journal of hypertension,
V Balasubramanian, and
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International journal of sports medicine,
V Balasubramanian, and
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E B Raftery, and
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November 2000,
Alternative therapies in health and medicine,
V Balasubramanian, and
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E B Raftery, and
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D Altman
August 1986,
Clinical pharmacology and therapeutics,
