BIOMAT Database Logo BIOMAT Database Logo

Monotherapy with labetalol for hypertensive patients with normal and impaired renal function. 1979

F D Thompson, and A M Joekes, and M M Hussein

1 Labetalol was given to 41 hypertensive patients in a divided dosage of 150--2,400 mg daily for periods ranging from 1--64 months. 2 Monotherapy with labetalol was adequate in 12 out of 19 patients with essential hypertension and in 15 out of the 22 with renal hypertension. 3 Following a single dose of labetalol 200 mg orally a hypotensive response was seen between 1.5 and 2 hours. 4 In the doses used there was no exercise or postural hypotension. 5 No reduction in overall renal function attributable to labetalol was seen.

UI MeSH Term Description Entries
D006973 Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. Blood Pressure, High,Blood Pressures, High,High Blood Pressure,High Blood Pressures
D007674 Kidney Diseases Pathological processes of the KIDNEY or its component tissues. Disease, Kidney,Diseases, Kidney,Kidney Disease
D007741 Labetalol A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS. AH-5158,Albetol,Apo-Labetalol,Dilevalol,Labetalol Hydrochloride,Labetalol, (R,R)-Isomer,Labetolol,Normodyne,Presolol,R,R-Labetalol,SCH-19927,Trandate,AH 5158,AH5158,Apo Labetalol,ApoLabetalol,Hydrochloride, Labetalol,R,R Labetalol,SCH 19927,SCH19927
D011187 Posture The position or physical attitude of the body. Postures
D011674 Pulse The rhythmical expansion and contraction of an ARTERY produced by waves of pressure caused by the ejection of BLOOD from the left ventricle of the HEART as it contracts. Pulses
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D003404 Creatinine Creatinine Sulfate Salt,Krebiozen,Salt, Creatinine Sulfate,Sulfate Salt, Creatinine
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004983 Ethanolamines AMINO ALCOHOLS containing the ETHANOLAMINE; (-NH2CH2CHOH) group and its derivatives. Aminoethanols
D005082 Physical Exertion Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included. Physical Effort,Effort, Physical,Efforts, Physical,Exertion, Physical,Exertions, Physical,Physical Efforts,Physical Exertions

Related Publications

F D Thompson, and A M Joekes, and M M Hussein
Labetalol in the treatment of hypertension in patients with normal and impaired renal function.
January 1982, Acta medica Scandinavica. Supplementum,
F D Thompson, and A M Joekes, and M M Hussein
Pindolol availability in hypertensive patients with normal and impaired renal function.
November 1977, Clinical pharmacology and therapeutics,
F D Thompson, and A M Joekes, and M M Hussein
Pharmacokinetics of lisinopril in hypertensive patients with normal and impaired renal function.
January 1988, European journal of clinical pharmacology,
F D Thompson, and A M Joekes, and M M Hussein
Labetalol as monotherapy in hypertensive black patients.
December 1985, Journal of clinical hypertension,
F D Thompson, and A M Joekes, and M M Hussein
Pharmacokinetics and pharmacodynamics of benazepril in hypertensive patients with normal and impaired renal function.
September 1992, Journal of cardiovascular pharmacology,
F D Thompson, and A M Joekes, and M M Hussein
[Renal and adrenal function following acute administration of urapidil in hypertensive patients with normal and impaired renal function].
August 1987, Arzneimittel-Forschung,
F D Thompson, and A M Joekes, and M M Hussein
Pharmacokinetics and antihypertensive effects of lisinopril in hypertensive patients with normal and impaired renal function.
October 1990, Journal of cardiovascular pharmacology,
F D Thompson, and A M Joekes, and M M Hussein
Stereoselective pharmacokinetics of oral nitrendipine in elderly hypertensive patients with normal and impaired renal function.
January 1992, European journal of clinical pharmacology,
F D Thompson, and A M Joekes, and M M Hussein
Pharmacokinetics and hepatic extraction ratio of pindolol in hypertensive patients with normal and impaired renal function.
January 1977, Journal of clinical pharmacology,
F D Thompson, and A M Joekes, and M M Hussein
Renal and systemic effects of continued treatment with renin inhibitor remikiren in hypertensive patients with normal and impaired renal function.
May 2000, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
Copied contents to your clipboard!