Biomaterial Database

Distribution of fluid between extracellular and intracellular compartments in the heart, lungs, liver and spleen of neonatal rats. 1979

C E Johanson

The volume of fluid in various tissue compartments of thoracic and abdominal viscera in neonatal rats has been calculated from the steady state distribution of radioindicators. During the first 3 weeks after birth, the volume of extracellular fluid (3H-inulin space) decreases at a similar rate (ca. 0.04 ml/g tissue/week) in heart, lungs, liver and spleen. Over the same postnatal period, the 51Cr tagged erythrocyte space (an estimate of vascularity) remains relatively constant in liver, increases slightly in the heart and spleen, and rises substantially (3-fold increase) in the lungs. The volume of parenchymal cell water, calculated from data for tissue water content and radioindicator spaces, tends to increase with age. However, the distribution of fluid between extracellular and intracellular compartments in 3-week-old animals is similar to that in adults.

UI	MeSH Term	Description	Entries
D007444	Inulin	A starch found in the tubers and roots of many plants. Since it is hydrolyzable to FRUCTOSE, it is classified as a fructosan. It has been used in physiologic investigation for determination of the rate of glomerular function.
D008168	Lung	Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.	Lungs
D008954	Models, Biological	Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.	Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D009206	Myocardium	The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.	Muscle, Cardiac,Muscle, Heart,Cardiac Muscle,Myocardia,Cardiac Muscles,Heart Muscle,Heart Muscles,Muscles, Cardiac,Muscles, Heart
D001834	Body Water	Fluids composed mainly of water found within the body.	Water, Body
D004911	Erythrocyte Volume	Volume of circulating ERYTHROCYTES . It is usually measured by RADIOISOTOPE DILUTION TECHNIQUE.	Red Cell Mass,Erythrocyte Volumes,Mass, Red Cell,Masses, Red Cell,Red Cell Masses,Volume, Erythrocyte,Volumes, Erythrocyte
D005110	Extracellular Space	Interstitial space between cells, occupied by INTERSTITIAL FLUID as well as amorphous and fibrous substances. For organisms with a CELL WALL, the extracellular space includes everything outside of the CELL MEMBRANE including the PERIPLASM and the cell wall.	Intercellular Space,Extracellular Spaces,Intercellular Spaces,Space, Extracellular,Space, Intercellular,Spaces, Extracellular,Spaces, Intercellular
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000831	Animals, Newborn	Refers to animals in the period of time just after birth.	Animals, Neonatal,Animal, Neonatal,Animal, Newborn,Neonatal Animal,Neonatal Animals,Newborn Animal,Newborn Animals
D013154	Spleen	An encapsulated lymphatic organ through which venous blood filters.