Polymorphic hydroxylation of debrisoquine in Ghanaians [proceedings].
1979
B Andoh, and
J R Idle, and
A Mahgoub, and
T P Sloan, and
R L Smith, and
N Woolhouse
UI
MeSH Term
Description
Entries
D007546
Isoquinolines
A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. The ring structure is characteristic of the group of opium alkaloids such as papaverine. (From Stedman, 25th ed)
D008297
Male
Males
D010641
Phenotype
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Phenotypes
D003647
Debrisoquin
An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Debrisoquine,Tendor
D005260
Female
Females
D005869
Ghana
A republic in western Africa, south of BURKINA FASO and west of TOGO. Its capital is Accra.
Gold Coast,Republic of Ghana
D006801
Humans
Members of the species Homo sapiens.
Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006900
Hydroxylation
Placing of a hydroxyl group on a compound in a position where one did not exist before. (Stedman, 26th ed)
Hydroxylations
D000328
Adult
A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.
Adults
D044383
Black People
Persons having origins in any of the black racial groups of AFRICA. Note that OMB category BLACK OR AFRICAN AMERICAN is available for the United States population groups. Race and ethnicity terms, as used in the federal government, are self-identified social construct and may include terms outdated and offensive in MeSH to assist users who are interested in retrieving comprehensive search results for studies such as in longitudinal studies.