Biomaterial Database

Human cutaneous vulvar reactivity to irritants. 1979

M B Britz, and H I Maibach

To better understand the cutaneous reactivity of vulvar skin, two chemical irritants were applied topically to 21 subjects. The forearm of each subject served as a comparative control. Test sites remained open and were read at 24 hours. A significantly increased response to the irritants was noted on the vulvar skin.

UI	MeSH Term	Description	Entries
D008298	Maleates	Derivatives of maleic acid (the structural formula (COO-)-C
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D004890	Erythema	Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of disease processes.	Erythemas
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000287	Administration, Topical	The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.	Drug Administration, Topical,Administration, Topical Drug,Topical Administration,Topical Drug Administration,Administrations, Topical,Administrations, Topical Drug,Drug Administrations, Topical,Topical Administrations,Topical Drug Administrations
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D001548	Benzalkonium Compounds	A mixture of alkylbenzyldimethylammonium compounds. It is a bactericidal quaternary ammonium detergent used topically in medicaments, deodorants, mouthwashes, as a surgical antiseptic, and as a as preservative and emulsifier in drugs and cosmetics.	Benzalkonium,Benzalkonium Chloride,Alkyldimethylbenzylammonium Chloride,Asepsol,BTC-2125,Drapolene,Germex,Osvan,Zephiran,BTC 2125,BTC2125,Chloride, Alkyldimethylbenzylammonium,Chloride, Benzalkonium,Compounds, Benzalkonium
D014847	Vulvitis	Inflammation of the VULVA. It is characterized by PRURITUS and painful urination.	Vulvitides