-transparent.png){kind=logo}
The secondary structure of the cyclic moiety of oxytocin and deamino-oxytocin has been determined by nuclear magnetic resonance spectroscopy (220 MHz). Oxytocin, in a dimethylsulfoxide-methanol mixture, contains a beta-turn involving the sequence -L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-. Deamino-oxytocin, in addition to the beta-turn, contains a hydrogen bond involving the amide hydrogen of the tyrosine residue and the peptide carbonyl group of the asparagine residue, resulting in an antiparallel beta-type conformation for the ring component. An initial attempt has been made to relate conformational features of the hormonal peptides to their biological activity.
D W Urry, and
M Ohnishi, and
R Walter
August 1966,
Journal of the American Chemical Society,
D W Urry, and
M Ohnishi, and
R Walter
December 1972,
Proceedings of the National Academy of Sciences of the United States of America,
D W Urry, and
M Ohnishi, and
R Walter
September 1965,
Journal of the American Chemical Society,
D W Urry, and
M Ohnishi, and
R Walter
May 1986,
Science (New York, N.Y.),
D W Urry, and
M Ohnishi, and
R Walter
August 1980,
International journal of peptide and protein research,
D W Urry, and
M Ohnishi, and
R Walter
January 1965,
Endocrinology,
D W Urry, and
M Ohnishi, and
R Walter
September 1965,
Journal of the American Chemical Society,
D W Urry, and
M Ohnishi, and
R Walter
June 1969,
Experientia,
D W Urry, and
M Ohnishi, and
R Walter
November 1973,
European journal of pharmacology,
D W Urry, and
M Ohnishi, and
R Walter
September 1966,
The Journal of biological chemistry,
