Bile acid clearance in liver disease. 1979

L K Luey, and K W Heaton

The disappearance of intravenously administered cholylglycine-14C was studied in the fasting and postprandial states in seven subjects with healthy livers and 10 patients with liver disease. In neither group was there any significant difference in the pattern of 14C disappearance. In another 10 patients with liver disease there was no significant change when a loading dose of cholylglycine was given orally two hours beforehand. Clearance of bile acids seems to be unimpaired in all except severe liver disease. The apparent deterioration in endogenous bile acid removal after meals may be due simply to the increased amount of bile acids which are in circulation and available for portosystemic shunting.

UI MeSH Term Description Entries
D008107 Liver Diseases Pathological processes of the LIVER. Liver Dysfunction,Disease, Liver,Diseases, Liver,Dysfunction, Liver,Dysfunctions, Liver,Liver Disease,Liver Dysfunctions
D008297 Male Males
D008657 Metabolic Clearance Rate Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site. Total Body Clearance Rate,Clearance Rate, Metabolic,Clearance Rates, Metabolic,Metabolic Clearance Rates,Rate, Metabolic Clearance,Rates, Metabolic Clearance
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D005215 Fasting Abstaining from FOOD. Hunger Strike,Hunger Strikes,Strike, Hunger,Strikes, Hunger
D005260 Female Females
D005502 Food Substances taken in by the body to provide nourishment. Foods
D006000 Glycocholic Acid The glycine conjugate of CHOLIC ACID. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Cholylglycine,Glycine Cholate,Glycocholate,Glycocholate Sodium,Glycocholic Acid, Sodium Salt
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

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