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The baboon, Papio, has been found to be a model for the study of the pathogenesis of cholesterol cholelithiasis in man. Studies of the physiologic variations in hepatic bile composition indicate a cyclic pattern to the proportions of cholesterol, lecithin, and bile salt in hepatic bile. During reabsorption of the bile salt pool from the intestines (stimulated flow), hepatic bile is characteristically undersaturated with cholesterol. After reabsorption of the bile salt pool (basal flow), hepatic bile is characteristically supersaturated with cholesterol. This typical pattern of basal and stimulated hepatic bile occurs irrespective of the presence of cholesterol stones in the baboon. Recognition of these two types of hepatic bile and their interrelationship during admixture in the gallbladder provides new insight into the pathogenesis of gallstone formation.
C K McSherry, and
F Glenn, and
N B Javitt
March 1970,
The American journal of digestive diseases,
C K McSherry, and
F Glenn, and
N B Javitt
June 1993,
Gastroenterologia Japonica,
C K McSherry, and
F Glenn, and
N B Javitt
October 1972,
Gut,
C K McSherry, and
F Glenn, and
N B Javitt
October 1976,
The Journal of laboratory and clinical medicine,
C K McSherry, and
F Glenn, and
N B Javitt
October 1991,
Annals of surgery,
C K McSherry, and
F Glenn, and
N B Javitt
June 1972,
The Journal of clinical investigation,
C K McSherry, and
F Glenn, and
N B Javitt
January 1975,
Acta chirurgica Scandinavica,
C K McSherry, and
F Glenn, and
N B Javitt
January 1977,
Medicinski pregled,
C K McSherry, and
F Glenn, and
N B Javitt
July 2008,
Nature medicine,
C K McSherry, and
F Glenn, and
N B Javitt
January 2015,
Microbial pathogenesis,
