-transparent.png){kind=logo}
A radioenzymatic assay was employed to measure the accumulation of DOPA in a variety of rat brain tissues 30 min after the administration of a decarboxylase inhibitor in order to estimate the activity of dopamine (DA) nerves which terminate in these regions. In the median eminence and posterior pituitary the accumulation of DOPA appears to occur primarily in DA nerves since: (1) the rate of synthesis of norepinephrine (NE), as estimated from the alpha-methyltyrosine-induced decline of catecholamines, accounts for less than 10% of total catecholamine synthesis in these two brain regions; and (2) the accumulation of DOPA is not significantly altered when the NE concentrations in these regions are reduced to 40--50% of control by prior intraventricular injections of 6-hydroxydopamine. These results suggest that the accumulation of DOPA in the median eminence and the posterior pituitary can be used to estimate the activity of tubero-infundibular and tuberohypophyseal DA nerves, respectively.
K T Demarest, and
R H Alper, and
K E Moore
October 1990,
Brain research,
K T Demarest, and
R H Alper, and
K E Moore
August 1979,
Brain research,
K T Demarest, and
R H Alper, and
K E Moore
August 1991,
Brain research,
K T Demarest, and
R H Alper, and
K E Moore
June 1975,
Endocrinology,
K T Demarest, and
R H Alper, and
K E Moore
May 1989,
Neuroendocrinology,
K T Demarest, and
R H Alper, and
K E Moore
February 2007,
Neuroscience,
K T Demarest, and
R H Alper, and
K E Moore
February 1980,
Endocrinology,
K T Demarest, and
R H Alper, and
K E Moore
December 1973,
Endocrinology,
K T Demarest, and
R H Alper, and
K E Moore
September 1990,
Endocrinologia experimentalis,
K T Demarest, and
R H Alper, and
K E Moore
August 1973,
Endocrinology,
