Biomaterial Database

Observations on "lung shift" after chemotherapy in mice infected with Schistosoma mansoni. 1965

G Dickerson

It is known from work with Puerto Rican strains of Schistosoma mansoni that in experimental bilharziasis in laboratory animals there may be a shift of flukes from the mesenteric vessels to the lungs, and that this occurs both in untreated animals and in those given chemotherapy. The work reported in this paper was undertaken to study this phenomenon with an Egyptian strain of S. mansoni.With but one exception, no schistosomes were found in groups of untreated mice autopsied 6-12 weeks after infection. Some were found in the lungs of a few mice treated 6 weeks after infection and more in the lungs of those treated 10 weeks after infection.A shift of flukes to the lungs appears to be dependent upon a number of linked factors. In the study reported, the important factor was the effect of an active compound which resulted in a passive shift of flukes from their normal sites in the mesenteric vessels. Possible routes by which schistosomes may reach the lungs are discussed.

UI	MeSH Term	Description	Entries
D008174	Lung Diseases, Parasitic	Infections of the lungs with parasites, most commonly by parasitic worms (HELMINTHS).	Parasitic Lung Diseases,Parasitic Infections of Lung,Pulmonary Parasitic Infections,Lung Disease, Parasitic,Lung Parasitic Infection,Lung Parasitic Infections,Parasitic Infection, Pulmonary,Parasitic Infections, Pulmonary,Parasitic Lung Disease,Pulmonary Parasitic Infection
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000981	Antiprotozoal Agents	Substances that are destructive to protozoans.	Schizonticides,Agents, Antiprotozoal
D012552	Schistosomiasis	Infection with flukes (trematodes) of the genus SCHISTOSOMA. Three species produce the most frequent clinical diseases: SCHISTOSOMA HAEMATOBIUM (endemic in Africa and the Middle East), SCHISTOSOMA MANSONI (in Egypt, northern and southern Africa, some West Indies islands, northern 2/3 of South America), and SCHISTOSOMA JAPONICUM (in Japan, China, the Philippines, Celebes, Thailand, Laos). S. mansoni is often seen in Puerto Ricans living in the United States.	Bilharziasis,Katayama Fever,Schistoma Infection,Bilharziases,Fever, Katayama,Infection, Schistoma,Infections, Schistoma,Schistoma Infections,Schistosomiases
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus