In 25 patients with angiographically proven coronary heart disease and in 15 patients without heart disease, gated cardiac blood pool scintigraphy was done with 15 mCi 99mTc-HSA in LAO projection. Scintigraphic data were collected in list mode by means of a gamma camera connected to a computer system (Siemens 330). A cumulative scintigram scintigram sequence with a time resolution of 100, 50 and 25 frames/sec was constructed using several hundred heart cycles of equal duration. After background correction volume curves of the left ventricle with a time resolution of 25, 50 and 100 Hz were obtained and the following parameters of these curves were compaired: ejection fraction, maximum ejection rate and maximum filling rate. It could be demonstrated that smoothing by sliding average requires a time resolution of at least 50 Hz, whereas in volume curves smoothed by Fourier-Analysis a time resolution of only 25 Hz is necessary. However, using a time resolution of 25 Hz, the course of the volume curve can not always be clearly demonstrated, so that time resolution of 50 Hz combined with Fourier-Analysis for the gated cardiac blood pool scintigraphy is preferred.