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The effects of purine deoxyribonucleosides on bromodeoxyurdine (BrdU) mutagenesis in Syrian hamster melanoma cells were determined. Both deoxyguanosine (dG) and deoxyadenosine (dA) were found to stimulate mutagenesis without changing the amount of BrdU in DNA. In addition, the stimulation of mutagenesis by dG and dA was suppressed by the addition of deoxycytidine (dC). These results suggest that BrdU mutagenesis involves the perturbation of dC metabolism, which perturbation is enhanced by dGTP and dATP. The mutagenic activity of dG in the absence of BrdU was tested, as was that of thymidine (dT), which we had shown previously to stimulate BrdU mutageneis. With dG alone, no increase above the spontaneous mutation frequency was detected. However, at extremely high concentration, dT in the absence of BrdU was slightly mutagenic, and the mutagenesis by dT was enhanced by dG and suppressed by dC.
E R Kaufman, and
R L Davidson
March 1981,
Molecular and cellular biology,
E R Kaufman, and
R L Davidson
November 1985,
Molecular and cellular biology,
E R Kaufman, and
R L Davidson
March 2000,
Journal of cell science,
E R Kaufman, and
R L Davidson
July 1991,
Somatic cell and molecular genetics,
E R Kaufman, and
R L Davidson
January 1987,
Biochemistry,
E R Kaufman, and
R L Davidson
January 1976,
Mutation research,
E R Kaufman, and
R L Davidson
April 1984,
Cancer research,
E R Kaufman, and
R L Davidson
January 1980,
Pharmacology & therapeutics,
E R Kaufman, and
R L Davidson
June 1974,
Cell,
E R Kaufman, and
R L Davidson
June 1973,
Journal of cellular physiology,
