Biomaterial Database

[Regeneration of defects in a small portion of the urinary bladder mucosa in experiments with guinea pigs]. 1979

J Gotovac

Regeneration of the vesical mucosa begins from the remains of the bladder at the trigonum and urethra, and the author studied this regeneration in 30 rats. Epithelial regeneration began on the third day after formation of the defect. On the fifth day the entire defect was covered with transitional epithelium whose thickness did not exceed 1--2 cell layers. During the fifth week regeneration was complete. This experiment confirms the claim of Baker et al. the regeneration of the mucossa of the urinary bladder (except for the remaining mucosa of the trigonum and urethra) occurs via differentiation of pluripotential mesenchyme cells into transitional epithelium. During the experiment, the rats were given garamycin prophylactically. The very short regeneration time was probably due to the absence of any inflammatory process.

UI	MeSH Term	Description	Entries
D009092	Mucous Membrane	An EPITHELIUM with MUCUS-secreting cells, such as GOBLET CELLS. It forms the lining of many body cavities, such as the DIGESTIVE TRACT, the RESPIRATORY TRACT, and the reproductive tract. Mucosa, rich in blood and lymph vessels, comprises an inner epithelium, a middle layer (lamina propria) of loose CONNECTIVE TISSUE, and an outer layer (muscularis mucosae) of SMOOTH MUSCLE CELLS that separates the mucosa from submucosa.	Lamina Propria,Mucosa,Mucosal Tissue,Muscularis Mucosae,Mucous Membranes,Membrane, Mucous,Membranes, Mucous,Mucosae, Muscularis,Mucosal Tissues,Propria, Lamina,Tissue, Mucosal,Tissues, Mucosal
D012038	Regeneration	The physiological renewal, repair, or replacement of tissue.	Endogenous Regeneration,Regeneration, Endogenous,Regenerations
D001743	Urinary Bladder	A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION.	Bladder,Bladder Detrusor Muscle,Detrusor Urinae,Bladder Detrusor Muscles,Bladder, Urinary,Detrusor Muscle, Bladder,Detrusor Muscles, Bladder
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia