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A 3 month old girl with congenital syphilis presented with the nephrotic syndrome due to extra membranous glomerulonephritis. The presence of the first component of the classical pathway of complement activation (C1q) in the glomerular deposits and the antitreponemal antibodies in circulating cryoglobulins (titre 1 : 320) support the hypothesis that immune complexes are responsbile for the glomerulonephritis in congenital syphilis.
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