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The responsiveness of the hepatic supernatant NAD+-dependent aldehyde dehydrogenase with a high Km value (high Km-AldDH) to phenobarbital (PB) and 3-methylcholanthrene (3-MC) treatment was studied in male rats of three strains; Wistar, Long-Evans, and Sprague-Dawley. A remarkable strain difference in the response of the enzyme to PB or 3-MC was observed. In rats of the Wistar strain the enzyme activity remained unchanged ("non-responsive") in all rats after treatment with PB while it increased ("responsive") 5- to 19-fo-d in all rats after treatment with 3-MC. The enzyme activity increased 8- to 20-fold and 2- to 8-fold respectively after treatment with PB and 3-MC in all rats of the Long-Evans strain. In rats of the Sprague-Dawley strain the enzyme activity remained unchanged in half of all the rats treated with PB or 3-MC and increased 2- to 7-fold over the basal level in half of the treated rats. The non-responsive rats to PB were all responsive to 3-MC treatment while the responsive rats to PB were responsive in 65% and non-responsive in 35% to 3-MC treatment.
S Nakanishi, and
E Shiohara, and
M Tsukada, and
H Yamazaki, and
K Nishiguchi, and
R Saladin
November 1972,
The Journal of biological chemistry,
S Nakanishi, and
E Shiohara, and
M Tsukada, and
H Yamazaki, and
K Nishiguchi, and
R Saladin
July 1971,
Science (New York, N.Y.),
S Nakanishi, and
E Shiohara, and
M Tsukada, and
H Yamazaki, and
K Nishiguchi, and
R Saladin
April 1967,
Nature,
S Nakanishi, and
E Shiohara, and
M Tsukada, and
H Yamazaki, and
K Nishiguchi, and
R Saladin
September 1977,
The Journal of biological chemistry,
S Nakanishi, and
E Shiohara, and
M Tsukada, and
H Yamazaki, and
K Nishiguchi, and
R Saladin
September 1988,
Toxicology and applied pharmacology,
S Nakanishi, and
E Shiohara, and
M Tsukada, and
H Yamazaki, and
K Nishiguchi, and
R Saladin
January 1989,
Pharmacology & toxicology,
S Nakanishi, and
E Shiohara, and
M Tsukada, and
H Yamazaki, and
K Nishiguchi, and
R Saladin
February 1975,
Experimental and molecular pathology,
S Nakanishi, and
E Shiohara, and
M Tsukada, and
H Yamazaki, and
K Nishiguchi, and
R Saladin
July 1979,
Biochemical pharmacology,
S Nakanishi, and
E Shiohara, and
M Tsukada, and
H Yamazaki, and
K Nishiguchi, and
R Saladin
November 1975,
Biochimica et biophysica acta,
S Nakanishi, and
E Shiohara, and
M Tsukada, and
H Yamazaki, and
K Nishiguchi, and
R Saladin
June 1986,
Cell biology and toxicology,
