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1 Twenty-four Asian vegetarians had significantly lower 25-hydroxyvitamin D (25-OHD) levels and longer antipyrine half-lives than twenty white non-vegetarians (P less than 0.001). 2 Treatment with oral antipyrine over 4 or 5 weeks in seven vegetarian Asians and five racially different non-vegetarians increased drug oxidation significantly in both groups as measured by a fall in antipyrine half-lives and a rise in serum gamma-glutamyltranspeptidase levels and urinary 6 beta-hydroxycortisol/17-hydroxycorticosteroid ratios. 3 Antipyrine treatment produced a fall in circulating 25-hydroxyvitamin D of around 60% in all subjects in whom pretreatment levels could be measured, independent of race and diet. 4. In the Caucasian non-vegetarian group 1,25 dihidroxyvitamin D levels, the most active metabolite of vitamin D, were also measured and remained unaltered despite a substantial fall in 25-hydroxy substrate. 5 The acute fall in 25-hydroxyvitamin D concentration with a maintained level of 1,25 dihidroxyvitamin D may represent the early changes of drug-induced osteomalacia.
P F Wilmana, and
M J Brodie, and
J C Mucklow, and
H S Fraser, and
E L Toverud, and
D S Davies, and
C T Dollery, and
C J Hillyard, and
I Macintyre, and
B K Park
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P F Wilmana, and
M J Brodie, and
J C Mucklow, and
H S Fraser, and
E L Toverud, and
D S Davies, and
C T Dollery, and
C J Hillyard, and
I Macintyre, and
B K Park
July 1974,
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P F Wilmana, and
M J Brodie, and
J C Mucklow, and
H S Fraser, and
E L Toverud, and
D S Davies, and
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C J Hillyard, and
I Macintyre, and
B K Park
July 2013,
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P F Wilmana, and
M J Brodie, and
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P F Wilmana, and
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J C Mucklow, and
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E L Toverud, and
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C T Dollery, and
C J Hillyard, and
I Macintyre, and
B K Park
May 2004,
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P F Wilmana, and
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I Macintyre, and
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P F Wilmana, and
M J Brodie, and
J C Mucklow, and
H S Fraser, and
E L Toverud, and
D S Davies, and
C T Dollery, and
C J Hillyard, and
I Macintyre, and
B K Park
January 2013,
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P F Wilmana, and
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J C Mucklow, and
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E L Toverud, and
D S Davies, and
C T Dollery, and
C J Hillyard, and
I Macintyre, and
B K Park
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P F Wilmana, and
M J Brodie, and
J C Mucklow, and
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E L Toverud, and
D S Davies, and
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C J Hillyard, and
I Macintyre, and
B K Park
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P F Wilmana, and
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J C Mucklow, and
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E L Toverud, and
D S Davies, and
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C J Hillyard, and
I Macintyre, and
B K Park
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