-transparent.png){kind=logo}
Benzoylacetonitrile and beta-aminocinnamonitrile are shown to possess potent antiinflammatory activity in the rat adjuvant arthritis model. In a series of phenyl-substituted analogues, only o-, m-, and p-fluorobenzoylacetonitrile and m- and p-fluoro-beta-aminocinnamonitrile retained activity. Additionally, beta-amino-2- and beta-amino-3-thiopheneacrylonitrile and beta-oxo-2- and beta-oxo-3-thiophenepropionitrile exhibited similar activity. These agents are not believed to be acting via prostaglandin synthetase inhibition. The metabolic profile of benzoylacetonitrile is also described.
Related Publications
D N Ridge, and
J W Hanifin, and
L A Harten, and
B D Johnson, and
J Menschik, and
G Nicolau, and
A E Sloboda, and
D E Watts
January 1992,
Journal of medicinal chemistry,
D N Ridge, and
J W Hanifin, and
L A Harten, and
B D Johnson, and
J Menschik, and
G Nicolau, and
A E Sloboda, and
D E Watts
November 1987,
Seminars in arthritis and rheumatism,
D N Ridge, and
J W Hanifin, and
L A Harten, and
B D Johnson, and
J Menschik, and
G Nicolau, and
A E Sloboda, and
D E Watts
October 1978,
Journal of medicinal chemistry,
D N Ridge, and
J W Hanifin, and
L A Harten, and
B D Johnson, and
J Menschik, and
G Nicolau, and
A E Sloboda, and
D E Watts
January 2006,
Current pharmaceutical design,
D N Ridge, and
J W Hanifin, and
L A Harten, and
B D Johnson, and
J Menschik, and
G Nicolau, and
A E Sloboda, and
D E Watts
January 1985,
Annals of the New York Academy of Sciences,
D N Ridge, and
J W Hanifin, and
L A Harten, and
B D Johnson, and
J Menschik, and
G Nicolau, and
A E Sloboda, and
D E Watts
February 1980,
JAMA,
D N Ridge, and
J W Hanifin, and
L A Harten, and
B D Johnson, and
J Menschik, and
G Nicolau, and
A E Sloboda, and
D E Watts
August 1984,
Comprehensive therapy,
D N Ridge, and
J W Hanifin, and
L A Harten, and
B D Johnson, and
J Menschik, and
G Nicolau, and
A E Sloboda, and
D E Watts
March 1986,
Chemical & pharmaceutical bulletin,
D N Ridge, and
J W Hanifin, and
L A Harten, and
B D Johnson, and
J Menschik, and
G Nicolau, and
A E Sloboda, and
D E Watts
January 2023,
Journal of Ayurveda and integrative medicine,
D N Ridge, and
J W Hanifin, and
L A Harten, and
B D Johnson, and
J Menschik, and
G Nicolau, and
A E Sloboda, and
D E Watts
January 1993,
Journal of medicinal chemistry,
