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Following i.v. administration of mono-HR to the beagle, plasma levels of both mono-HR and its glucuronide conjugates fell rapidly, neither being detectable 8 h after injection. Following oral administration of 14C-mono-HR, mono-HR-glucuronide was detected in plasma, confirming the absorption of mono-HR, and low levels of 14C were detectable up to 72 h after dosage. Following either oral or i.v. administration of mono-HR, the major route of excretion was fecal elimination of the compound as its aglycone form. Urinary excretion was slight being less than 15% following i.v. dosage and 4% following oral administration. Metabolism of mono-HR was confined to glucuronidation and hydrolytic cleavage of the glycoside side chain. Ring fission products of mono-HR were not detected.
A M Hackett, and
L A Griffiths
April 1974,
Archives internationales de pharmacodynamie et de therapie,
A M Hackett, and
L A Griffiths
January 1974,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
A M Hackett, and
L A Griffiths
September 2002,
European journal of clinical pharmacology,
A M Hackett, and
L A Griffiths
May 1972,
Klinische Monatsblatter fur Augenheilkunde,
A M Hackett, and
L A Griffiths
January 1974,
Xenobiotica; the fate of foreign compounds in biological systems,
A M Hackett, and
L A Griffiths
May 2011,
Drug metabolism and disposition: the biological fate of chemicals,
A M Hackett, and
L A Griffiths
September 1992,
Ugeskrift for laeger,
A M Hackett, and
L A Griffiths
August 1978,
Journal of pharmaceutical sciences,
A M Hackett, and
L A Griffiths
November 1972,
Xenobiotica; the fate of foreign compounds in biological systems,
A M Hackett, and
L A Griffiths
February 1977,
AJR. American journal of roentgenology,
