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The action of d-psuedoephedrine on bronchial smooth muscle, respiratory resistance and blood pressure was compared with that of 1-ephedrine. The following results were obtained. 1) Administration of dl-isoproterenol on isolated guinea pig tracheal muscle previously constricted with acetylcholine (ACh) or histamine (his) was the most effective and d-pseudoephedrine had the same effect as 1-ephedrine. The relaxing effect of dl-isoproterenol, 1-ephedrine or d-pseudoephedrine on ACh or His induced tracheal constriction was competitively antagonized by the pretreatment of propranolol. 2) The intravenous or sublingual administration of d-pseudoephedrine on the increased respiratory resistance induced by His produced the same effect as 1-ephedrine. 3) The increase in blood pressure with d-pseudoephedrine was weaker than that of 1-ephedrine. 4) When 1-ephedrine of d-pseudoephedrine was repeatedly injected into the same animal, signs of tachyphylaxis were observed. It was found that d-pseudoephedrine, the main alkaloid of Ephedrine Helba, exhibited the relaxing effect on bronchial smooth muscles as did 1-ephedrine. The respiratory resistance increased by His was inhibited by the sublingual administration of d-pseudoephedrine and 1-ephedrine.
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Praxis und Klinik der Pneumologie,
K Akiba, and
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May 1975,
Praxis der Pneumologie,
K Akiba, and
A Miyamoto, and
T Suzuki, and
K Anezaki, and
T Tadano, and
S Sakurada, and
K Kisara
February 1981,
Masui. The Japanese journal of anesthesiology,
K Akiba, and
A Miyamoto, and
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K Anezaki, and
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March 1979,
Laryngologie, Rhinologie, Otologie,
K Akiba, and
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S Sakurada, and
K Kisara
November 1978,
Nihon Jinzo Gakkai shi,
K Akiba, and
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June 1982,
Zhongguo yao li xue bao = Acta pharmacologica Sinica,
K Akiba, and
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Praktische Anasthesie, Wiederbelebung und Intensivtherapie,
K Akiba, and
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K Anezaki, and
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S Sakurada, and
K Kisara
January 1975,
Annales de chirurgie thoracique et cardio-vasculaire,
K Akiba, and
A Miyamoto, and
T Suzuki, and
K Anezaki, and
T Tadano, and
S Sakurada, and
K Kisara
January 1975,
Annales de chirurgie thoracique et cardio-vasculaire,
K Akiba, and
A Miyamoto, and
T Suzuki, and
K Anezaki, and
T Tadano, and
S Sakurada, and
K Kisara
March 1977,
Therapeutische Umschau. Revue therapeutique,
