Biomaterial Database

Fibrinogenolysis and fibrinolysis with strenuous exercise. 1979

E W Ferguson, and C F Barr, and L L Bernier

Twenty healthy young men were exercised on a treadmill according to the protocol of Balke and Ware. Mean duration of exercise was 24.9 +/- 5.7 min and mean maximum heart rate was 195 +/- 9. Fibrinolytic activity was markedly accelerated with euglobulin lysis times decreasing to 36% of control values and fibrinogen-fibrin degradation products increasing 109% after exercise. Assays for fibrin monomer were negative in all samples. In vivo fibrinogen A alpha-chin degradation was assessed by sodium dodecyl sulfate polyacrylamide gel electrophoresis of reduced samples of fibrin monomer isolated by clotting plasma samples in the presence of 0.1 M epsilon-aminocaproic acid and 1% disodium ethylenediaminetetraacetate. The A alpha-chain, the fibrinogen chain most susceptible to plasmin degeneration, showed no evidence of increased degeneration after exercise. Gel scans showed no decrease in the ratio of total alpha-chain to beta- and gamma-chains after exercise. The ratio of intact alpha 1 chain (alpha 1, 67,000 mol wt) to total alpha-chain was 0.66 +/- 0.13 before exercise, 0.64 +/- 0.14 immediately after exercise, and 0.65 +/- 0.13 1 h after exercise. The rate and extent of crosslinking of the alpha-chain of fibrin formed by clotting plasma samples was unaltered by exericse. These data suggest that physiologically significant fibrinogenolysis does not occur with strenuous exercise, even when fibrinolytic activity is markedly accelerated.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008970	Molecular Weight	The sum of the weight of all the atoms in a molecule.	Molecular Weights,Weight, Molecular,Weights, Molecular
D001779	Blood Coagulation Factors	Endogenous substances, usually proteins, that are involved in the blood coagulation process.	Clotting Factor,Coagulation Factors,Blood Coagulation Factor,Clotting Factors,Coagulation Factor,Coagulation Factor, Blood,Coagulation Factors, Blood,Factor, Coagulation,Factors, Coagulation,Factor, Blood Coagulation,Factor, Clotting,Factors, Blood Coagulation,Factors, Clotting
D005082	Physical Exertion	Expenditure of energy during PHYSICAL ACTIVITY. Intensity of exertion may be measured by rate of OXYGEN CONSUMPTION; HEAT produced, or HEART RATE. Perceived exertion, a psychological measure of exertion, is included.	Physical Effort,Effort, Physical,Efforts, Physical,Exertion, Physical,Exertions, Physical,Physical Efforts,Physical Exertions
D005338	Fibrin Fibrinogen Degradation Products	Soluble protein fragments formed by the proteolytic action of plasmin on fibrin or fibrinogen. FDP and their complexes profoundly impair the hemostatic process and are a major cause of hemorrhage in intravascular coagulation and fibrinolysis.	Antithrombin VI,Fibrin Degradation Product,Fibrin Degradation Products,Fibrin Fibrinogen Split Products,Degradation Product, Fibrin,Degradation Products, Fibrin,Product, Fibrin Degradation
D005340	Fibrinogen	Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.	Coagulation Factor I,Factor I,Blood Coagulation Factor I,gamma-Fibrinogen,Factor I, Coagulation,gamma Fibrinogen
D005342	Fibrinolysis	The natural enzymatic dissolution of FIBRIN.	Fibrinolyses
D006400	Hematocrit	The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.	Erythrocyte Volume, Packed,Packed Red-Cell Volume,Erythrocyte Volumes, Packed,Hematocrits,Packed Erythrocyte Volume,Packed Erythrocyte Volumes,Packed Red Cell Volume,Packed Red-Cell Volumes,Red-Cell Volume, Packed,Red-Cell Volumes, Packed,Volume, Packed Erythrocyte,Volume, Packed Red-Cell,Volumes, Packed Erythrocyte,Volumes, Packed Red-Cell
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults