Biomaterial Database

[Beta-receptor blocking drugs and the bronchial system. A comparative study of pindolol and metoprolol (author's transl)]. 1979

P von Wichert, and J Boes

Effects of the beta 2-receptor stimulating drug fenoterol were investigated after administration of beta-receptor blocking agents in 12 patients with obstructive respiratory disease and a hyperreactive bronchial system (positive acetylcholine test). In a double blind trial pindolol (universal beta-receptor blocking drug) and metoprolol (a cardioselective substance) were compared after administration of equally effective doses of 5 and 100 mg respectively. Whole-body plethysmography showed that both beta-receptor blocking drugs caused no bronchial constriction; the bronchodilating effects of fenoterol were not reduced. These findings must cast doubt on the differentiation between cardioselective and non-cardioselective beta-receptor blocking agents as far as practical therapeutic implications are concerned.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008790	Metoprolol	A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.	Beloc-Duriles,Betaloc,Betaloc-Astra,Betalok,CGP-2175,H 93-26,Lopressor,Metoprolol CR-XL,Metoprolol Succinate,Metoprolol Tartrate,Seloken,Spesicor,Spesikor,Toprol,Toprol-XL,Beloc Duriles,Betaloc Astra,CGP 2175,CGP2175,H 93 26,H 9326,Metoprolol CR XL,Toprol XL
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D010869	Pindolol	A moderately lipophilic beta blocker (ADRENERGIC BETA-ANTAGONISTS). It is non-cardioselective and has intrinsic sympathomimetic actions, but little membrane-stabilizing activity. (From Martindale, The Extra Pharmocopoeia, 30th ed, p638)	Prindolol,LB-46,Visken,LB 46,LB46
D010993	Plethysmography, Whole Body	Measurement of the volume of gas in the lungs, including that which is trapped in poorly communicating air spaces. It is of particular use in chronic obstructive pulmonary disease and emphysema. (Segen, Dictionary of Modern Medicine, 1992)	Whole Body Plethysmography,Body Plethysmographies, Whole,Body Plethysmography, Whole,Plethysmographies, Whole Body,Whole Body Plethysmographies
D011412	Propanolamines	AMINO ALCOHOLS containing the propanolamine (NH2CH2CHOHCH2) group and its derivatives.	Aminopropanols
D001991	Bronchitis	Inflammation of the large airways in the lung including any part of the BRONCHI, from the PRIMARY BRONCHI to the TERTIARY BRONCHI.	Bronchitides
D005260	Female		Females
D005280	Fenoterol	A synthetic adrenergic beta-2 agonist that is used as a bronchodilator and tocolytic.	Berotec,Berotek,Fenoterol Hydrobromide,Fenoterol Hydrochloride,Partusisten,Phenoterol,Th-1165a,p-Hydroxyphenyl-orciprenaline,p-Hydroxyphenylorciprenaline,Hydrochloride, Fenoterol,Th 1165a,Th1165a,p Hydroxyphenyl orciprenaline,p Hydroxyphenylorciprenaline
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man