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18-substituted steroids. Part 4. A chemical synthesis of 3 alpha,18,21-trihydroxy-5 beta-pregnan-20-one 18--20-hemiacetal (18-hydroxy-tetrahydro-DOC). 1979

M Hossain, and D N Kirk

3 alpha,18,21-Trihydroxy-5 beta-pregnan-20-one 18 leads to 20-hemiacetal (18-hydroxy-tetrahydro-DOC) has been prepared from 3 alpha-acetoxy-5 beta-pregnan-20-one by reduction to the 20 beta-alcohol, application of the 'hypoiodite' reaction [Pb(OAc)4-I2-hv] with subsequent steps leading to the 18-hydroxy-20-ketone (as hemiacetal), and C-21 acetoxylation [Pb(OAc)4] followed by hydrolysis.

UI MeSH Term Description Entries
D003900 Desoxycorticosterone A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE 21-Hydroxyprogesterone,Cortexone,Deoxycorticosterone,Desoxycortone,11-Decorticosterone,21-Hydroxy-4-pregnene-3,20-dione,11 Decorticosterone,21 Hydroxy 4 pregnene 3,20 dione,21 Hydroxyprogesterone
D015070 18-Hydroxydesoxycorticosterone An analog of desoxycorticosterone which is substituted by a hydroxyl group at the C-18 position. 18 Hydroxydesoxycorticosterone,18-Hydroxy-11-Deoxycorticosterone,18-Hydroxy-11-Desoxycorticosterone,18 Hydroxy 11 Deoxycorticosterone,18 Hydroxy 11 Desoxycorticosterone,Hydroxydesoxycorticosterone, 18

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