A survey is given on the therapy of lymphogranulomatosis. Keystones of the treatment are radiotherapy, antineoplastic chemotherapy and supportive measures of treatment. A therapy referred to diagnosis and stages including a clinical and pathological staging proves to be necessary in every case. The initial treatment consists in a radiotherapy in the stages I, II and III A, in a polychemotherapy according to the scheme MOPP and COPP, respectively, or CVPP in the stages III B and IV as well as possibly in a combined treatment in histomorphologically unfavourable forms also already in the early stages. The problems of the MOPP alternative programmes in primary failures, of the programmes of the post-MOPP-therapy in secondary failures and recidivations as well as of the remission-keeping long-term therapy need a further clarification. It is referred to the dangers and side-effects of an aggressive radio- and chemotherapy.