-transparent.png){kind=logo}
A thin-layer chromatographic method has been developed for the detection and measurement of N-trifluoroacetyladriamycin-14-valerate (AD 32) and its major metabolite trifluoroacetyladriamycin (AD 41). The procedure gives satisfactory linearity over a large range of concentrations. The coefficient of variability is about 10% over the entire range of usable concentrations, giving good reproducibility; sensitivity is 25 ng for both AD 32 and AD 41. Analysis is specific for AD 32 and AD 41 since adriamycin or more polar metabolites can be differentiated. Recovery is high (85-90%) and the method is simple and economical to use. Pharmacokinetics of AD 32 and AD 41 are reported in blood and some tissues of mice bearing Lewis Lung carcinoma.
B Barbieri, and
R Abbruzzi, and
A Benigni, and
M Rizzardini, and
M G Donelli, and
S Garattini, and
M Salmona
April 1985,
Teratology,
B Barbieri, and
R Abbruzzi, and
A Benigni, and
M Rizzardini, and
M G Donelli, and
S Garattini, and
M Salmona
May 1979,
Cancer treatment reports,
B Barbieri, and
R Abbruzzi, and
A Benigni, and
M Rizzardini, and
M G Donelli, and
S Garattini, and
M Salmona
January 1991,
Cancer chemotherapy and pharmacology,
B Barbieri, and
R Abbruzzi, and
A Benigni, and
M Rizzardini, and
M G Donelli, and
S Garattini, and
M Salmona
January 1987,
Cancer chemotherapy and pharmacology,
B Barbieri, and
R Abbruzzi, and
A Benigni, and
M Rizzardini, and
M G Donelli, and
S Garattini, and
M Salmona
February 1992,
Biochemical pharmacology,
B Barbieri, and
R Abbruzzi, and
A Benigni, and
M Rizzardini, and
M G Donelli, and
S Garattini, and
M Salmona
January 1980,
Cancer chemotherapy and pharmacology,
B Barbieri, and
R Abbruzzi, and
A Benigni, and
M Rizzardini, and
M G Donelli, and
S Garattini, and
M Salmona
January 1978,
Cancer treatment reports,
B Barbieri, and
R Abbruzzi, and
A Benigni, and
M Rizzardini, and
M G Donelli, and
S Garattini, and
M Salmona
January 1978,
Cancer treatment reports,
B Barbieri, and
R Abbruzzi, and
A Benigni, and
M Rizzardini, and
M G Donelli, and
S Garattini, and
M Salmona
March 1997,
Urology,
B Barbieri, and
R Abbruzzi, and
A Benigni, and
M Rizzardini, and
M G Donelli, and
S Garattini, and
M Salmona
June 1976,
Cancer research,
