Biomaterial Database

The in vitro stability of [131I]o-iodohippurate. 1979

C E Hotte, and R D Ice

The kinetics of [131I]o-iodohippurate (OIH) decomposition were evaluated to develop an accelerated technique for the prediction of radiopharmaceutical stability. Decomposition due to temperature and self-absorbed radiation was characterized simultaneously. Using the proposed technique, the extent of OIH decomposition was calculated a priori to be 7.6% over a 28-day period when extrapolated to a specific concentration of 2 mCi/ml and a storage of 25 degrees C. Extended storage under these same conditions yielded a mean decomposition value of 8.0% over an equivalent time interval. The techniques developed offer a rapid means of accurately assessing the stability of new radiopharmaceuticals as they are developed.

UI	MeSH Term	Description	Entries
D007457	Iodine Radioisotopes	Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.	Radioisotopes, Iodine
D007465	Iodohippuric Acid	An iodine-containing compound used in pyelography as a radiopaque medium. If labeled with radioiodine, it can be used for studies of renal function.	Iodobenzoylglycine,Sodium Iodohippurate,I-Hippuran,I-OIH,Orthoiodohippurate,Radio-Hippuran,Sodium o-Iodohippurate,ortho-Iodohippurate,Acid, Iodohippuric,I Hippuran,I OIH,Iodohippurate, Sodium,Radio Hippuran,RadioHippuran,Sodium o Iodohippurate,o-Iodohippurate, Sodium,ortho Iodohippurate
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D011854	Radiochemistry	The study of the chemical and physical phenomena of radioactive substances.	Radiochemistries
D004355	Drug Stability	The chemical and physical integrity of a pharmaceutical product.	Drug Shelf Life,Drugs Shelf Lives,Shelf Life, Drugs,Drug Stabilities,Drugs Shelf Life,Drugs Shelf Live,Life, Drugs Shelf,Shelf Life, Drug,Shelf Live, Drugs,Shelf Lives, Drugs
D013696	Temperature	The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.	Temperatures
D066298	In Vitro Techniques	Methods to study reactions or processes taking place in an artificial environment outside the living organism.	In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In