-transparent.png){kind=logo}
The action of the convulsant drugs, methionine sulfoximine (MSO), 3-mercaptopropionate (3-MP), megimide (MG), and allylglycine on the binding of L-[14C]aspartate, L-[14C]glutamate and [14C]GABA to a hydrophobic protein fraction isolated from rat cerebral cortex was studied. Using the convulsant at 10(-4) M concentration and the radioactive ligands as 10(-6) M the binding of L-[14C]glutamate was inhibited 60% by 3-MP and 40% by MSO, while MG and allylglycine had no effect. The binding of L-[14C]aspartate was inhibited 55%, and 10--20% by 3-MP and MSO, respectively, while MG and allylglycine had not effect. None of the drugs mentioned, except for a minimal inhibition by MG, altered the binding of [14C]GABA. Neither MSO nor 3-MP affected the high-affinity sites for L-[14C]glutamate of L-[14C]aspartate, but they had a strong inhibitory action on the medium affinity site. These results are discussed in relation to the possible mechanism of action of these drugs on L-glutamate and L-aspartate receptors.
U C Sábato, and
S Fiszer de Plazas, and
E De Robertis
March 1976,
Nature,
U C Sábato, and
S Fiszer de Plazas, and
E De Robertis
January 1982,
Physiological chemistry and physics,
U C Sábato, and
S Fiszer de Plazas, and
E De Robertis
June 1970,
Proceedings of the National Academy of Sciences of the United States of America,
U C Sábato, and
S Fiszer de Plazas, and
E De Robertis
February 1984,
Neurochemical research,
U C Sábato, and
S Fiszer de Plazas, and
E De Robertis
July 1990,
Neuroscience letters,
U C Sábato, and
S Fiszer de Plazas, and
E De Robertis
February 1976,
Neurochemical research,
U C Sábato, and
S Fiszer de Plazas, and
E De Robertis
January 1966,
Life sciences,
U C Sábato, and
S Fiszer de Plazas, and
E De Robertis
March 1981,
Journal of neurochemistry,
U C Sábato, and
S Fiszer de Plazas, and
E De Robertis
October 1976,
Journal of neurochemistry,
U C Sábato, and
S Fiszer de Plazas, and
E De Robertis
September 2013,
Synapse (New York, N.Y.),
