-transparent.png){kind=logo}
Total serum copper levels produced by the administration of a single dose of cuprous oxide (500 mg/kg) both s.c. and orally to rats and guinea pigs are reported 1, 5, 7 and 24 h after administration, together with caeruloplasmin oxidase activities and changes in the sulphydryl group concentrations. The highest serum copper levels were obtained one hour after oral administration to the guinea pig. Both animal species exhibited increased serum copper levels after s.c. administration and this increase persisted for a longer time than after oral administration. Caeruloplasmin oxidase activity varied in a complex manner and sulphydryl group activity was significantly depressed in all cases except after s.c. administration to the guinea pig. The latter results must be treated cautiously since they may indicate interactions between copper and the test procedures. Analysis of serum fractions separated by electrophoresis indicated that the absorbed copper is mainly transported on albumin. The dissolution of cuprous oxide by amino acids and hydrochloric acid and the absorption of cuprous oxidcations of the results are discussed in terms of their relevance to pharmacological and clinical studies.
D H Brown, and
J Dunlop, and
W E Smith, and
J Teape
January 1978,
Drug metabolism and disposition: the biological fate of chemicals,
D H Brown, and
J Dunlop, and
W E Smith, and
J Teape
January 1994,
Archives internationales de pharmacodynamie et de therapie,
D H Brown, and
J Dunlop, and
W E Smith, and
J Teape
January 1965,
Acta biologica et medica Germanica,
D H Brown, and
J Dunlop, and
W E Smith, and
J Teape
January 1989,
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,
D H Brown, and
J Dunlop, and
W E Smith, and
J Teape
January 1964,
Bulletin de la Societe de pathologie exotique et de ses filiales,
D H Brown, and
J Dunlop, and
W E Smith, and
J Teape
January 1990,
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
D H Brown, and
J Dunlop, and
W E Smith, and
J Teape
September 1989,
New Zealand veterinary journal,
D H Brown, and
J Dunlop, and
W E Smith, and
J Teape
June 2023,
Chemistry (Weinheim an der Bergstrasse, Germany),
D H Brown, and
J Dunlop, and
W E Smith, and
J Teape
January 1991,
Poultry science,
D H Brown, and
J Dunlop, and
W E Smith, and
J Teape
June 1947,
The Journal of clinical endocrinology and metabolism,
