Biomaterial Database

Geographical disproportions of multiple sclerosis in Czechoslovakia. 1979

P Lensky

In the sanatorium in Vráz near Pisek in 1970-1978 3310 patients with multiple sclerosis received spa treatment. By analysis of their birth place, domicile at age of 15 years and present domicile we tried to assess the geographical distribution of the disease in Czechoslovakia. The area of the suspected highest frequency of MS is the northwestern part of Bohemia with the maximum near Teplice and Most. The lowest frequency was recorded in the lowland areas of southern Moravia and southern Slovakia including Bratislava. The frequency gradient from the north-west towards the south-east, the demarcation line formed by the 49th northern parallel and some ecological relations are very striking and deserve further research and confirmation.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009103	Multiple Sclerosis	An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)	MS (Multiple Sclerosis),Multiple Sclerosis, Acute Fulminating,Sclerosis, Disseminated,Disseminated Sclerosis,Sclerosis, Multiple
D003604	Czechoslovakia	Created as a republic in 1918 by Czechs and Slovaks from territories formerly part of the Austro-Hungarian Empire. The country split into the Czech Republic and Slovakia 1 January 1993.
D005260	Female		Females
D005843	Geography	The science dealing with the earth and its life, especially the description of land, sea, and air and the distribution of plant and animal life, including humanity and human industries with reference to the mutual relations of these elements. (From Webster, 3d ed)	Factor, Geographic,Factors, Geographic,Geographic Factor,Geographic Factors,Geography, Human,Human Geography
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man