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Glucose tolerance with serum insulin assay has been carried out in 24 apparently unaffected identical twins of diabetics. Glucose values were significantly higher and insulin values significantly lower than in control subjects, but there was considerable individual variation and in half the cases glucose tolerance was normal. There was no case of increased insulin response. In these twins glucose tolerance and insulin response were not correlated with weight, family history of diabetes, age at diagnosis of diabetes in the affected twin, time since that diagnosis, nor with age at testing the unaffected twin. On retesting 12 of the twins after two years no significant differences were found from the first testing.We conclude that not all these twins are likely to develop diabetes, that the assumption that identical twins of diabetics are necessarily "prediabetic" is probably erroneous, and that factors other than genetic ones are important in the aetiology of diabetes.
D A Pyke, and
J Cassar, and
J Todd, and
K W Taylor
October 1967,
British medical journal,
D A Pyke, and
J Cassar, and
J Todd, and
K W Taylor
October 1967,
British medical journal,
D A Pyke, and
J Cassar, and
J Todd, and
K W Taylor
August 1990,
Diabetologia,
D A Pyke, and
J Cassar, and
J Todd, and
K W Taylor
May 1970,
Deutsche medizinische Wochenschrift (1946),
D A Pyke, and
J Cassar, and
J Todd, and
K W Taylor
February 1997,
The American journal of physiology,
D A Pyke, and
J Cassar, and
J Todd, and
K W Taylor
January 1982,
Current problems in clinical biochemistry,
D A Pyke, and
J Cassar, and
J Todd, and
K W Taylor
September 1983,
The American journal of clinical nutrition,
D A Pyke, and
J Cassar, and
J Todd, and
K W Taylor
January 1982,
Osaka city medical journal,
D A Pyke, and
J Cassar, and
J Todd, and
K W Taylor
January 1995,
Metabolism: clinical and experimental,
D A Pyke, and
J Cassar, and
J Todd, and
K W Taylor
January 1971,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
