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Topically applied bupranolol, a beta-adrenergic blocking agent, has been shown to have a marked effectiveness in lowering the intraocular pressure of the normal and glaucomatous eyes. The effects were not only seen in the treated eyes but also in the untreated, contralateral eyes. The contralateral response was independent of the ongoing diurnal variation of the intraocular pressure. Instillation of the drug into the nasal cavity induced decrease of the intraocular pressure in both eyes, the extent of which was comparable to the contralateral response induced by ocular instillation. These observations suggest that the contralateral response is caused by systemically absorbed drug, probably due to the action on the central locus regulating the intraocular pressure. Instillation of pilocarpine did not show any similar contralateral response.
G Sakimoto, and
H Une, and
N Ohba
April 1977,
Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology,
G Sakimoto, and
H Une, and
N Ohba
May 1991,
Nippon Ganka Gakkai zasshi,
G Sakimoto, and
H Une, and
N Ohba
April 1987,
Canadian journal of ophthalmology. Journal canadien d'ophtalmologie,
G Sakimoto, and
H Une, and
N Ohba
October 1979,
Archives of ophthalmology (Chicago, Ill. : 1960),
G Sakimoto, and
H Une, and
N Ohba
September 1982,
American journal of ophthalmology,
G Sakimoto, and
H Une, and
N Ohba
February 2008,
American journal of veterinary research,
G Sakimoto, and
H Une, and
N Ohba
February 1977,
Experimental eye research,
G Sakimoto, and
H Une, and
N Ohba
August 1975,
Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology,
G Sakimoto, and
H Une, and
N Ohba
April 1988,
Transplantation proceedings,
G Sakimoto, and
H Une, and
N Ohba
May 1975,
Arzneimittel-Forschung,
