Biomaterial Database

[Principles of therapeutic trials (author's transl)]. 1979

J Lellouch

Therapeutic trials aim at comparing the effectiveness of two therapeutic attitudes. The problems involved are considered: comparability requirements of the groups, assured by randomization, which raises ethical questions. The need of a "sufficient" number of subjects, often imposing cooperative trials, is then discussed. Finally, it is necessary to define the disease and patients, the therapeutic possibilities, and judgement criteria.

UI	MeSH Term	Description	Entries
D011897	Random Allocation	A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.	Randomization,Allocation, Random
D002986	Clinical Trials as Topic	Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.	Clinical Trial as Topic
D004992	Ethics, Medical	The principles of professional conduct concerning the rights and duties of the physician, relations with patients and fellow practitioners, as well as actions of the physician in patient care and interpersonal relations with patient families.	Medical Ethics
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man