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It was found that lymphocytes cultured in the medium containing chyle were remarkably suppressed in responding to phytohemagglutinin as compared with the control culture without the fluid. This suppressive effect on the cell type seemed likely to be induced by cytotoxic substance produced from the fluid incubated. Various lipids were separated from the incubated-chyle by thin-layer and gas-liquid chromatographies and then their cytotoxic activity to the lymphocytes was examined. These experimental results suggested that unsaturated free fatty acids, made possibly from chylomicron by lipoprotein lipase, had a capability to cause lymphocytolysis. The patho-physiological and immunological significance of the cytotoxic products was discussed.
Y Kinoshita, and
T Nagasawa, and
S Kimura, and
K Kageyama, and
E Kimura
May 1976,
Clinical immunology and immunopathology,
Y Kinoshita, and
T Nagasawa, and
S Kimura, and
K Kageyama, and
E Kimura
December 1992,
Immunological investigations,
Y Kinoshita, and
T Nagasawa, and
S Kimura, and
K Kageyama, and
E Kimura
September 1971,
Journal of the Reticuloendothelial Society,
Y Kinoshita, and
T Nagasawa, and
S Kimura, and
K Kageyama, and
E Kimura
February 1950,
Blood,
Y Kinoshita, and
T Nagasawa, and
S Kimura, and
K Kageyama, and
E Kimura
January 1981,
Clinical immunology and immunopathology,
Y Kinoshita, and
T Nagasawa, and
S Kimura, and
K Kageyama, and
E Kimura
May 1966,
Nature,
Y Kinoshita, and
T Nagasawa, and
S Kimura, and
K Kageyama, and
E Kimura
December 1976,
Helvetica chirurgica acta,
Y Kinoshita, and
T Nagasawa, and
S Kimura, and
K Kageyama, and
E Kimura
January 1961,
Surgical forum,
Y Kinoshita, and
T Nagasawa, and
S Kimura, and
K Kageyama, and
E Kimura
March 1948,
Federation proceedings,
Y Kinoshita, and
T Nagasawa, and
S Kimura, and
K Kageyama, and
E Kimura
January 1987,
Intensive care medicine,
