-transparent.png){kind=logo}
Nt-Methylhistidine, a non-reutilised amino acid present in some myofibrillar proteins, was radioactively labelled in vivo with [Me-3H]methionine. The specific radioactivities of protein-bound methylhistidine and free methylhistidine in perfusate after perfusion of rat hind limbs taken from prelabelled rats was determined. The decrease in urinary methylhistidine activity with time was determined for rats similarly labelled. Comparison of the specific activities of free and bound methylhistidine and the non-linear semilogarithmic plot of urinary methylhistidine activity suggest that the myofibrillar protein catabolism, as indicated by methylhistidine release, may not be a simple exponential process. The possibility of non-random decay is discussed and an alternative model proposed.
L C Ward, and
P J Buttery
September 1988,
FEBS letters,
L C Ward, and
P J Buttery
October 1987,
The Biochemical journal,
L C Ward, and
P J Buttery
January 1994,
Life sciences,
L C Ward, and
P J Buttery
March 1991,
Metabolism: clinical and experimental,
L C Ward, and
P J Buttery
July 1989,
Metabolism: clinical and experimental,
L C Ward, and
P J Buttery
January 1987,
Diabetes,
L C Ward, and
P J Buttery
January 1981,
Muscle & nerve,
L C Ward, and
P J Buttery
November 1990,
Pflugers Archiv : European journal of physiology,
L C Ward, and
P J Buttery
January 1994,
Cancer letters,
L C Ward, and
P J Buttery
February 1991,
FEBS letters,
