Biomaterial Database

Reproductive dysfunction in male rats following neonatal administration of monosodium L-glutamate. 1979

W J Pizzi, and J E Barnhart, and J R Unnerstall

Monosodium glutamate (MSG) was administered to neonatal rats according to an increasing dose schedule from days 2-11 after birth. Adult MSG-treated male rats showed reproductive deficits along with stunted body lengths and reduced testes weights. These results demonstrate that MSG is capable of producing reproductive deficits in the rat similar to those seen in the mouse. These results are discussed in light of the methodological differences between those studies reporting positive or negative findings on reproductive function in MSG-treated mice and rats.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D009929	Organ Size	The measurement of an organ in volume, mass, or heaviness.	Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D012098	Reproduction	The total process by which organisms produce offspring. (Stedman, 25th ed)	Human Reproductive Index,Human Reproductive Indexes,Reproductive Period,Human Reproductive Indices,Index, Human Reproductive,Indexes, Human Reproductive,Indices, Human Reproductive,Period, Reproductive,Periods, Reproductive,Reproductive Index, Human,Reproductive Indices, Human,Reproductive Periods
D001724	Birth Weight	The mass or quantity of heaviness of an individual at BIRTH. It is expressed by units of pounds or kilograms.	Birthweight,Birth Weights,Birthweights,Weight, Birth,Weights, Birth
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D004702	Endocrine Glands	Ductless glands that secrete HORMONES directly into the BLOOD CIRCULATION. These hormones influence the METABOLISM and other functions of cells in the body.	Endocrine Gland,Gland, Endocrine
D005971	Glutamates	Derivatives of GLUTAMIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the 2-aminopentanedioic acid structure.	Glutamic Acid Derivatives,Glutamic Acids,Glutaminic Acids
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000831	Animals, Newborn	Refers to animals in the period of time just after birth.	Animals, Neonatal,Animal, Neonatal,Animal, Newborn,Neonatal Animal,Neonatal Animals,Newborn Animal,Newborn Animals
D012970	Sodium Glutamate	One of the FLAVORING AGENTS used to impart a meat-like flavor.	MSG,Monosodium Glutamate,Vestin,Accent,Glutamate, Sodium