BIOMAT Database Logo BIOMAT Database Logo

[Effect of ethylmaleimide on the transport of Ca+ and K+ ions across mitochondrial membranes]. 1979

N E Lofrumento, and F Zanotti, and A Pavone

As already reported, it has been found that the gradient of protons, set up across the inner membrane during the Ca2+ uptake by rat liver mitochondria, can be completely reversed by the addition of NEM. Identical results have been obtained by following the energy dependent K+ uptake. In these last conditions, the rate of H+ efflux supported by succinate oxidation is greatly enhanced only when NEM is added after rotenone. It is proposed that the increased rate other than to the inhibition of Pi uptake, as suggested by Reynafarje and Lehninger, could also be ascribed to a further decrease in the energetic level of the membrane as well as to an increased rate of succinate-Pi exchange diffusion reaction induced by NEM. A possible direct effect of NEM on succinate oxidation has been also considered to account for the inhibition observed when it is added before rotenone.

UI MeSH Term Description Entries
D007425 Intracellular Membranes Thin structures that encapsulate subcellular structures or ORGANELLES in EUKARYOTIC CELLS. They include a variety of membranes associated with the CELL NUCLEUS; the MITOCHONDRIA; the GOLGI APPARATUS; the ENDOPLASMIC RETICULUM; LYSOSOMES; PLASTIDS; and VACUOLES. Membranes, Intracellular,Intracellular Membrane,Membrane, Intracellular
D008930 Mitochondria, Liver Mitochondria in hepatocytes. As in all mitochondria, there are an outer membrane and an inner membrane, together creating two separate mitochondrial compartments: the internal matrix space and a much narrower intermembrane space. In the liver mitochondrion, an estimated 67% of the total mitochondrial proteins is located in the matrix. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p343-4) Liver Mitochondria,Liver Mitochondrion,Mitochondrion, Liver
D011188 Potassium An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
D002118 Calcium A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D005033 Ethylmaleimide A sulfhydryl reagent that is widely used in experimental biochemical studies. N-Ethylmaleimide,N Ethylmaleimide
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001692 Biological Transport The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments. Transport, Biological,Biologic Transport,Transport, Biologic
D012402 Rotenone A botanical insecticide that is an inhibitor of mitochondrial electron transport.
D013386 Succinates Derivatives of SUCCINIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain a 1,4-carboxy terminated aliphatic structure. Succinic Acids,Acids, Succinic
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

N E Lofrumento, and F Zanotti, and A Pavone
[Transport of ions and metabolites across mitochondrial membranes].
January 1966, Postepy biochemii,
N E Lofrumento, and F Zanotti, and A Pavone
[Transport of monovalent thallium ions across mitochondrial membranes].
February 1977, Doklady Akademii nauk SSSR,
N E Lofrumento, and F Zanotti, and A Pavone
[Coupled transport of H+, K+ and Cl minus ions across erythrocyte membranes].
December 1974, Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova,
N E Lofrumento, and F Zanotti, and A Pavone
Transport of ions across cellular membranes.
April 1949, Physiological reviews,
N E Lofrumento, and F Zanotti, and A Pavone
Transport of glutathione across the mitochondrial membranes.
February 1990, Biochemical and biophysical research communications,
N E Lofrumento, and F Zanotti, and A Pavone
Active transport of Ca ions across the rabbit cornea.
April 1960, The Japanese journal of physiology,
N E Lofrumento, and F Zanotti, and A Pavone
Effect of counter ions on the transport current across membranes containing KAT1 potassium channel.
January 2013, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry,
N E Lofrumento, and F Zanotti, and A Pavone
[The effect of physical factors on the active transport of sodium ions across cell membranes].
January 1997, Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury,
N E Lofrumento, and F Zanotti, and A Pavone
Influence of metal ions on the transport of ascorbate across membranes.
January 1986, International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
N E Lofrumento, and F Zanotti, and A Pavone
The transport of metabolites across the mitochondrial membranes.
April 1972, The Biochemical journal,
Copied contents to your clipboard!