Biomaterial Database

High performance liquid chromatographic analysis of hydrochlorothiazide in serum and urine. 1979

S J Soldin, and E Hach, and A Pollard, and A G Logan

We report a high performance liquid chromatographic method for the analysis of hydrochlorothiazide in 500microliter of serum of 25 microliter of urine. The between-day precision of the analysis (CV 5.0-7.0%) is acceptable, as is the recovery of hydrochlorothiazide (90-96%) and trichloromethiazide (96%) added to serum. No drug or drug metabolite interferences have been noted. The method represents a considerable improvement over existing techniques described in the literature.

UI	MeSH Term	Description	Entries
D002851	Chromatography, High Pressure Liquid	Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.	Chromatography, High Performance Liquid,Chromatography, High Speed Liquid,Chromatography, Liquid, High Pressure,HPLC,High Performance Liquid Chromatography,High-Performance Liquid Chromatography,UPLC,Ultra Performance Liquid Chromatography,Chromatography, High-Performance Liquid,High-Performance Liquid Chromatographies,Liquid Chromatography, High-Performance
D004347	Drug Interactions	The action of a drug that may affect the activity, metabolism, or toxicity of another drug.	Drug Interaction,Interaction, Drug,Interactions, Drug
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006852	Hydrochlorothiazide	A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.	Dichlothiazide,Dihydrochlorothiazide,Esidrex,Esidrix,HCTZ,HydroDIURIL,Hypothiazide,Oretic,Sectrazide